Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells - Evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells

Shin Ichi Suga, Hiroshi Itoh, Yasato Komatsu, Yoshihiro Ogawa, Norio Hama, Takaaki Yoshimasa, Kazuwa Nakao

Research output: Contribution to journalArticle

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Abstract

We previously demonstrated that C-type natriuretic peptide (CNP), originally isolated from the porcine brain, is produced by endothelial cells and proposed that CNP can exert local control over vascular tone and growth as a local regulator from endothelial cells. Since cytokines play pivotal roles in the control of vascular tone and structure, we have examined effects of various cytokines on CNP secretion from endothelial cells using the specific radioimmunoassay for CNP. While interleukin (IL)-2 had no significant effect on CNP secretion, IL-1α, IL-1β and tumor necrosis factor (TNF)-α stimulated CNP secretion in a time- and dose-dependent manner. Among them, TNF-α, one of the key mediators for inflammation and vascular remodeling, induced more than two orders of magnitude increase in CNP secretion. In addition, lipopolysaccharide (LPS) potently stimulated CNP secretion. These results indicate that IL-1, TNF-α and LPS, the endotoxin itself, can regulate local vascular tone and growth through the activation of CNP secretion from endothelial cells. Therefore, CNP could be of clinical relevance as an autocrine/paracrine regulator from endothelial cells for systemic and local cytokine-associated disorders, such as endotoxin shock and atherosclerosis.

Original languageEnglish
Pages (from-to)3038-3041
Number of pages4
JournalEndocrinology
Volume133
Issue number6
Publication statusPublished - 1993 Dec
Externally publishedYes

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C-Type Natriuretic Peptide
Endothelial Cells
Cytokines
Interleukin-1
Blood Vessels
Endotoxins
Lipopolysaccharides
Lymphotoxin-beta
Tumor Necrosis Factor-alpha
Inflammation Mediators
Growth
Radioimmunoassay
Interleukin-2
Shock
Atherosclerosis
Swine

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells - Evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells. / Suga, Shin Ichi; Itoh, Hiroshi; Komatsu, Yasato; Ogawa, Yoshihiro; Hama, Norio; Yoshimasa, Takaaki; Nakao, Kazuwa.

In: Endocrinology, Vol. 133, No. 6, 12.1993, p. 3038-3041.

Research output: Contribution to journalArticle

Suga, Shin Ichi ; Itoh, Hiroshi ; Komatsu, Yasato ; Ogawa, Yoshihiro ; Hama, Norio ; Yoshimasa, Takaaki ; Nakao, Kazuwa. / Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells - Evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells. In: Endocrinology. 1993 ; Vol. 133, No. 6. pp. 3038-3041.
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