Cytokine networks in the development of intestinal inflammation in Crohn's disease

Takanori Kanai, Mamoru Watanabe, Toshifumi Hibi

Research output: Contribution to journalArticle

Abstract

Crohn's disease (CD) affects more than 400,000 individuals in the United States and more than 18,000 in Japan. Its incidence is CD, one of the chronic inflammatory bowel diseases (IBD), is debilitating disorder of unknown ethiology, characterized by a marked accumulation of activated T cells and monocytes/macrophages in the inflamed mucosa. Various proinflammatory cytokines, such as TNF-α, INF-γ, IL-6, IL-12, and IL-18, might be involved in its pathogenesis. In this review, we describe the role of various cytokines in the development of CD and the new therapeutic trials modulating cytokine networks for the treatment of CD.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalFolia Pharmacologica Japonica
Volume120
Issue number1
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Crohn Disease
Cytokines
Inflammation
Interleukin-18
Interleukin-12
Inflammatory Bowel Diseases
Monocytes
Interleukin-6
Japan
Mucous Membrane
Macrophages
T-Lymphocytes
Incidence
Therapeutics

Keywords

  • Crohn's disease
  • Cytokine
  • IL-12
  • IL-18
  • TNF

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cytokine networks in the development of intestinal inflammation in Crohn's disease. / Kanai, Takanori; Watanabe, Mamoru; Hibi, Toshifumi.

In: Folia Pharmacologica Japonica, Vol. 120, No. 1, 2002, p. 39-45.

Research output: Contribution to journalArticle

@article{bdc8c7cdf5984fd7899918563e1739a5,
title = "Cytokine networks in the development of intestinal inflammation in Crohn's disease",
abstract = "Crohn's disease (CD) affects more than 400,000 individuals in the United States and more than 18,000 in Japan. Its incidence is CD, one of the chronic inflammatory bowel diseases (IBD), is debilitating disorder of unknown ethiology, characterized by a marked accumulation of activated T cells and monocytes/macrophages in the inflamed mucosa. Various proinflammatory cytokines, such as TNF-α, INF-γ, IL-6, IL-12, and IL-18, might be involved in its pathogenesis. In this review, we describe the role of various cytokines in the development of CD and the new therapeutic trials modulating cytokine networks for the treatment of CD.",
keywords = "Crohn's disease, Cytokine, IL-12, IL-18, TNF",
author = "Takanori Kanai and Mamoru Watanabe and Toshifumi Hibi",
year = "2002",
doi = "10.1254/fpj.120.39",
language = "English",
volume = "120",
pages = "39--45",
journal = "Folia Pharmacologica Japonica",
issn = "0015-5691",
publisher = "Japanese Pharmacological Society",
number = "1",

}

TY - JOUR

T1 - Cytokine networks in the development of intestinal inflammation in Crohn's disease

AU - Kanai, Takanori

AU - Watanabe, Mamoru

AU - Hibi, Toshifumi

PY - 2002

Y1 - 2002

N2 - Crohn's disease (CD) affects more than 400,000 individuals in the United States and more than 18,000 in Japan. Its incidence is CD, one of the chronic inflammatory bowel diseases (IBD), is debilitating disorder of unknown ethiology, characterized by a marked accumulation of activated T cells and monocytes/macrophages in the inflamed mucosa. Various proinflammatory cytokines, such as TNF-α, INF-γ, IL-6, IL-12, and IL-18, might be involved in its pathogenesis. In this review, we describe the role of various cytokines in the development of CD and the new therapeutic trials modulating cytokine networks for the treatment of CD.

AB - Crohn's disease (CD) affects more than 400,000 individuals in the United States and more than 18,000 in Japan. Its incidence is CD, one of the chronic inflammatory bowel diseases (IBD), is debilitating disorder of unknown ethiology, characterized by a marked accumulation of activated T cells and monocytes/macrophages in the inflamed mucosa. Various proinflammatory cytokines, such as TNF-α, INF-γ, IL-6, IL-12, and IL-18, might be involved in its pathogenesis. In this review, we describe the role of various cytokines in the development of CD and the new therapeutic trials modulating cytokine networks for the treatment of CD.

KW - Crohn's disease

KW - Cytokine

KW - IL-12

KW - IL-18

KW - TNF

UR - http://www.scopus.com/inward/record.url?scp=0036324516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036324516&partnerID=8YFLogxK

U2 - 10.1254/fpj.120.39

DO - 10.1254/fpj.120.39

M3 - Article

AN - SCOPUS:0036324516

VL - 120

SP - 39

EP - 45

JO - Folia Pharmacologica Japonica

JF - Folia Pharmacologica Japonica

SN - 0015-5691

IS - 1

ER -