Abstract
We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. Reverse transcription-polymerase chain reaction revealed that FGFs and HGF enhanced c-met expression. These findings suggest that c-Met expressed in astrocytes may have important roles during the nervous system regeneration.
Original language | English |
---|---|
Pages (from-to) | 105-110 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 962 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 2003 Feb 7 |
Externally published | Yes |
Keywords
- Astrocyte
- Double immunofluorescent staining
- RT-PCR
- Regeneration
- Western blot analysis
- c-Met
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology