Cytological features of signet-ring cell carcinoma of the lung: Comparison with the goblet-cell-type adenocarcinoma of the lung

Koji Tsuta, Yasuo Shibuki, Naoki Maezawa, Naobumi Tochigi, Akiko Miyagi Maeshima, Yuko Sasajima, Hisao Asamura, Yoshihiro Matsuno

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Signet-ring cell carcinoma (SRCC) and goblet-cell-type adeno-carcinoma (GCA) are mucin-producing lung adenocarcinomas. Primary SRCC shows an aggressive clinical course, whereas GCA shows infrequent distant metastasis, but more frequent intrapulmonary metastases resembling lobar pneumonia. To distinguish SRCC from GCA, this study investigated the respective cytological features of these lesions. We selected 10 cases each of SRCC and GCA from the archival imprint smears. We assessed them for the following 10 cytological features. Necrosis/debris was observed in 60% of the SRCC and 90% of the GCA. A muci-nous background was observed in 10% of the SRCC and 90% of the GCA. Significant inflammation was observed in none of the SRCC and 80% of the GCA. Stromal cluster was observed in 30% of the SRCC and 70% of the GCA. Nuclear overlapping was observed in 50% of the SRCC and in all of the GCA. Single tumor cells were observed in 80% of the SRCC and 10% of the GCA. Honeycomb-like cluster was observed in none of the SRCC and 80% of the GCA. Prominent nucleolus was observed in 50% of the SRCC and 40% of the GCA. Nuclear membrane irregularity was observed in 70% of SRCC and 60% of the GCA. Nuclear pleomorphism was observed in all of the SRCC and none of the GCA. The cytological features of SRCC were the presence of single tumor cells and nuclear pleomorphism, whereas that of GCA were the presence of abundant mucin and significant inflammation in the background, and a honeycomb-like cluster. Diagn.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalDiagnostic Cytopathology
Volume37
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1
Externally publishedYes

Keywords

  • Imprint smear
  • Lung adenocarcinoma
  • Mucinous-bronchiolo-alveolar carcinoma
  • Signet-ring cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Fingerprint

Dive into the research topics of 'Cytological features of signet-ring cell carcinoma of the lung: Comparison with the goblet-cell-type adenocarcinoma of the lung'. Together they form a unique fingerprint.

Cite this