Cytomegalovirus-associated biliary atresia

Kazuki Kodo, Kenichi Sakamoto, Tomohiko Imai, Takeshi Ota, Mitsuru Miyachi, Jun Mori, Tomohiro Chiyonobu, Tetsuya Imura, Hajime Hosoi

Research output: Contribution to journalArticle

Abstract

The pathogenesis of biliary atresia (BA) is propounded to be an immunological process, but the detailed mechanisms remain unclear. In recent studies with abnormal immunological findings, T cells have drawn attention in the mechanism of BA pathogenesis. Furthermore, cytomegalovirus (CMV) infection in BA patients resulted in elevated levels of helper T cells (Th1 and Th17) and reduction of regulatory T cells. Thus, CMV infection is considered as a cause of BA. We present the case of a 3-month-old boy who presented with intracerebral hemorrhage and finally died of liver failure. BA was diagnosed on autopsy and serum CMV-IgM was positive, but CMV antigen in the liver tissue was negative. Because CMV-associated BA has poor prognosis, compared with BA not associated with CMV, accurate classification of the type of BA is essential.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalJournal of Pediatric Surgery Case Reports
Volume35
DOIs
Publication statusPublished - 2018 Aug 1
Externally publishedYes

Fingerprint

Biliary Atresia
Cytomegalovirus
Cytomegalovirus Infections
Liver Failure
Cerebral Hemorrhage
Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Immunoglobulin M
Autopsy
T-Lymphocytes
Antigens
Liver

Keywords

  • Biliary atresia
  • Cytomegalovirus
  • Cytomegalovirus-associated biliary atresia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Kodo, K., Sakamoto, K., Imai, T., Ota, T., Miyachi, M., Mori, J., ... Hosoi, H. (2018). Cytomegalovirus-associated biliary atresia. Journal of Pediatric Surgery Case Reports, 35, 17-20. https://doi.org/10.1016/j.epsc.2018.02.002

Cytomegalovirus-associated biliary atresia. / Kodo, Kazuki; Sakamoto, Kenichi; Imai, Tomohiko; Ota, Takeshi; Miyachi, Mitsuru; Mori, Jun; Chiyonobu, Tomohiro; Imura, Tetsuya; Hosoi, Hajime.

In: Journal of Pediatric Surgery Case Reports, Vol. 35, 01.08.2018, p. 17-20.

Research output: Contribution to journalArticle

Kodo, K, Sakamoto, K, Imai, T, Ota, T, Miyachi, M, Mori, J, Chiyonobu, T, Imura, T & Hosoi, H 2018, 'Cytomegalovirus-associated biliary atresia', Journal of Pediatric Surgery Case Reports, vol. 35, pp. 17-20. https://doi.org/10.1016/j.epsc.2018.02.002
Kodo, Kazuki ; Sakamoto, Kenichi ; Imai, Tomohiko ; Ota, Takeshi ; Miyachi, Mitsuru ; Mori, Jun ; Chiyonobu, Tomohiro ; Imura, Tetsuya ; Hosoi, Hajime. / Cytomegalovirus-associated biliary atresia. In: Journal of Pediatric Surgery Case Reports. 2018 ; Vol. 35. pp. 17-20.
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