Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.)

Fumiyuki Kiuchi, Yumi Fukao, Takuro Maruyama, Tohru Obata, Motohiro Tanaka, Takuma Sasaki, Masayuki Mirage, Mohammad Ekramul Haque, Yoshisuke Tsuda

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O- β-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of 'akond mul' (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 μg/ml.

Original languageEnglish
Pages (from-to)528-530
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume46
Issue number3
DOIs
Publication statusPublished - 1998 Jan 1
Externally publishedYes

Keywords

  • Asclepiadaceae
  • Calotropin
  • Calotropis gigantea
  • Cardenolide
  • Cytotoxicity
  • Frugoside

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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    Kiuchi, F., Fukao, Y., Maruyama, T., Obata, T., Tanaka, M., Sasaki, T., Mirage, M., Haque, M. E., & Tsuda, Y. (1998). Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.). Chemical and Pharmaceutical Bulletin, 46(3), 528-530. https://doi.org/10.1248/cpb.46.528