Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.)

Fumiyuki Kiuchi; Yumi Fukao; Takuro Maruyama; Tohru Obata; Motohiro Tanaka; Takuma Sasaki; Masayuki Mirage; Mohammad Ekramul Haque; Yoshisuke Tsuda

doi:10.1248/cpb.46.528

Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.)

Fumiyuki Kiuchi, Yumi Fukao, Takuro Maruyama, Tohru Obata, Motohiro Tanaka, Takuma Sasaki, Masayuki Mirage, Mohammad Ekramul Haque, Yoshisuke Tsuda

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O- β-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of 'akond mul' (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 μg/ml.

Original language	English
Pages (from-to)	528-530
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	46
Issue number	3
DOIs	https://doi.org/10.1248/cpb.46.528
Publication status	Published - 1998
Externally published	Yes

Keywords

Asclepiadaceae
Calotropin
Calotropis gigantea
Cardenolide
Cytotoxicity
Frugoside

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.46.528

Cite this

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abstract = "Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O- β-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of 'akond mul' (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 μg/ml.",

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AU - Kiuchi, Fumiyuki

AU - Fukao, Yumi

AU - Maruyama, Takuro

AU - Obata, Tohru

AU - Tanaka, Motohiro

AU - Sasaki, Takuma

AU - Mirage, Masayuki

AU - Haque, Mohammad Ekramul

AU - Tsuda, Yoshisuke

PY - 1998

Y1 - 1998

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AB - Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O- β-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of 'akond mul' (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 μg/ml.

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KW - Cardenolide

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Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.)

Abstract

Keywords

ASJC Scopus subject areas

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