Cytotoxic substances from two species of Japanese sea hares: Chemistry and bioactivity

Kiyoyuki Yamada, Makoto Ojika, Hideo Kigoshi, Kiyotake Suenaga

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.

Original languageEnglish
Pages (from-to)176-189
Number of pages14
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume86
Issue number3
DOIs
Publication statusPublished - 2010 Mar

Keywords

  • Antitumor activity
  • Chemical structure
  • Chemical synthesis
  • Cytotoxic substances
  • Isolation
  • Sea hare

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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