Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs

Hideo Kigoshi, Kiyotake Suenaga, Masaki Takagi, Atsushi Akao, Kengo Kanematsu, Noriyuki Kamei, Youko Okugawa, Kiyoyuki Yamada

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Artificial analogs of aplyronine A (1), a potent antitumor macrolide, were synthesized and structure-activity (cytotoxicity and actin-depolymerizing activity) relationships were investigated; the side-chain in 1 was found to play a key role in both biological activities.

Original languageEnglish
Pages (from-to)1075-1102
Number of pages28
JournalTetrahedron
Volume58
Issue number6
DOIs
Publication statusPublished - 2002 Feb 4
Externally publishedYes

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Macrolides
Cytotoxicity
Bioactivity
Actins
aplyronine A

Keywords

  • Actin-depolymerizing
  • Analogs
  • Cytotoxicty
  • Marine metabolites
  • Structure-activity
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs. / Kigoshi, Hideo; Suenaga, Kiyotake; Takagi, Masaki; Akao, Atsushi; Kanematsu, Kengo; Kamei, Noriyuki; Okugawa, Youko; Yamada, Kiyoyuki.

In: Tetrahedron, Vol. 58, No. 6, 04.02.2002, p. 1075-1102.

Research output: Contribution to journalArticle

Kigoshi, Hideo ; Suenaga, Kiyotake ; Takagi, Masaki ; Akao, Atsushi ; Kanematsu, Kengo ; Kamei, Noriyuki ; Okugawa, Youko ; Yamada, Kiyoyuki. / Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs. In: Tetrahedron. 2002 ; Vol. 58, No. 6. pp. 1075-1102.
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