Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs

Hideo Kigoshi, Kiyotake Suenaga, Masaki Takagi, Atsushi Akao, Kengo Kanematsu, Noriyuki Kamei, Youko Okugawa, Kiyoyuki Yamada

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Artificial analogs of aplyronine A (1), a potent antitumor macrolide, were synthesized and structure-activity (cytotoxicity and actin-depolymerizing activity) relationships were investigated; the side-chain in 1 was found to play a key role in both biological activities.

Original languageEnglish
Pages (from-to)1075-1102
Number of pages28
JournalTetrahedron
Volume58
Issue number6
DOIs
Publication statusPublished - 2002 Feb 4
Externally publishedYes

Keywords

  • Actin-depolymerizing
  • Analogs
  • Cytotoxicty
  • Marine metabolites
  • Structure-activity
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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