Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga, Noriyuki Kamei, Youko Okugawa, Masaki Takagi, Atsushi Akao, Hideo Kigoshi, Kiyoyuki Yamada

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number3
DOIs
Publication statusPublished - 1997 Feb 4
Externally publishedYes

Fingerprint

Macrolides
Cytotoxicity
Bioactivity
Actins
aplyronine A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. / Suenaga, Kiyotake; Kamei, Noriyuki; Okugawa, Youko; Takagi, Masaki; Akao, Atsushi; Kigoshi, Hideo; Yamada, Kiyoyuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 3, 04.02.1997, p. 269-274.

Research output: Contribution to journalArticle

Suenaga, Kiyotake ; Kamei, Noriyuki ; Okugawa, Youko ; Takagi, Masaki ; Akao, Atsushi ; Kigoshi, Hideo ; Yamada, Kiyoyuki. / Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 3. pp. 269-274.
@article{b3ccbcf6fcab4d16b8f3a7b0d2fae559,
title = "Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs",
abstract = "The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.",
author = "Kiyotake Suenaga and Noriyuki Kamei and Youko Okugawa and Masaki Takagi and Atsushi Akao and Hideo Kigoshi and Kiyoyuki Yamada",
year = "1997",
month = "2",
day = "4",
doi = "10.1016/S0960-894X(96)00620-8",
language = "English",
volume = "7",
pages = "269--274",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

AU - Suenaga, Kiyotake

AU - Kamei, Noriyuki

AU - Okugawa, Youko

AU - Takagi, Masaki

AU - Akao, Atsushi

AU - Kigoshi, Hideo

AU - Yamada, Kiyoyuki

PY - 1997/2/4

Y1 - 1997/2/4

N2 - The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

AB - The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

UR - http://www.scopus.com/inward/record.url?scp=0031552092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031552092&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(96)00620-8

DO - 10.1016/S0960-894X(96)00620-8

M3 - Article

VL - 7

SP - 269

EP - 274

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 3

ER -