Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga; Noriyuki Kamei; Youko Okugawa; Masaki Takagi; Atsushi Akao; Hideo Kigoshi; Kiyoyuki Yamada

doi:10.1016/S0960-894X(96)00620-8

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga, Noriyuki Kamei, Youko Okugawa, Masaki Takagi, Atsushi Akao, Hideo Kigoshi, Kiyoyuki Yamada

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

Original language	English
Pages (from-to)	269-274
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(96)00620-8
Publication status	Published - 1997 Feb 4
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0960-894X(96)00620-8

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title = "Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs",

abstract = "The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.",

author = "Kiyotake Suenaga and Noriyuki Kamei and Youko Okugawa and Masaki Takagi and Atsushi Akao and Hideo Kigoshi and Kiyoyuki Yamada",

note = "Funding Information: We are grateful to Prof. Hirokazu Hotani, Drs. Tomohiko Itoh and Kingo Takiguchi (Department of Molecular Biology, Faculty of Science, Nagoya University) for donation of actin and their helpful advice and discussions. We thank Dr. Hisao Ekimoto and Ms. Mutsuko KJmura (Nippon Kayaku Co., Ltd.) for evaluating the cytotoxicity of the natural and synthetic compounds. This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas (Natural Supramolecules), for COE Research (No. 07CE2004), and for Encouragement of Young Scientists (No. 08780542) from the Ministry of Education, Science, and Culture, Japan, the Fujisawa Foundation, and Ono Pharmaceutical Co.",

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doi = "10.1016/S0960-894X(96)00620-8",

language = "English",

volume = "7",

pages = "269--274",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

AU - Suenaga, Kiyotake

AU - Kamei, Noriyuki

AU - Okugawa, Youko

AU - Takagi, Masaki

AU - Akao, Atsushi

AU - Kigoshi, Hideo

AU - Yamada, Kiyoyuki

N1 - Funding Information: We are grateful to Prof. Hirokazu Hotani, Drs. Tomohiko Itoh and Kingo Takiguchi (Department of Molecular Biology, Faculty of Science, Nagoya University) for donation of actin and their helpful advice and discussions. We thank Dr. Hisao Ekimoto and Ms. Mutsuko KJmura (Nippon Kayaku Co., Ltd.) for evaluating the cytotoxicity of the natural and synthetic compounds. This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas (Natural Supramolecules), for COE Research (No. 07CE2004), and for Encouragement of Young Scientists (No. 08780542) from the Ministry of Education, Science, and Culture, Japan, the Fujisawa Foundation, and Ono Pharmaceutical Co.

PY - 1997/2/4

Y1 - 1997/2/4

N2 - The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

AB - The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

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DO - 10.1016/S0960-894X(96)00620-8

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EP - 274

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Abstract

ASJC Scopus subject areas

UN SDGs

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