Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga, Noriyuki Kamei, Youko Okugawa, Masaki Takagi, Atsushi Akao, Hideo Kigoshi, Kiyoyuki Yamada

Research output: Contribution to journal › Article

46 Citations (Scopus)

Abstract

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number3
DOIs
Publication statusPublished - 1997 Feb 4
Externally publishedYes

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Macrolides
Cytotoxicity
Bioactivity
Actins
aplyronine A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. / Suenaga, Kiyotake; Kamei, Noriyuki; Okugawa, Youko; Takagi, Masaki; Akao, Atsushi; Kigoshi, Hideo; Yamada, Kiyoyuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 3, 04.02.1997, p. 269-274.

Research output: Contribution to journal › Article

Suenaga, K, Kamei, N, Okugawa, Y, Takagi, M, Akao, A, Kigoshi, H & Yamada, K 1997, 'Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs', Bioorganic and Medicinal Chemistry Letters, vol. 7, no. 3, pp. 269-274. https://doi.org/10.1016/S0960-894X(96)00620-8
Suenaga K, Kamei N, Okugawa Y, Takagi M, Akao A, Kigoshi H et al. Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. Bioorganic and Medicinal Chemistry Letters. 1997 Feb 4;7(3):269-274. https://doi.org/10.1016/S0960-894X(96)00620-8
Suenaga, Kiyotake ; Kamei, Noriyuki ; Okugawa, Youko ; Takagi, Masaki ; Akao, Atsushi ; Kigoshi, Hideo ; Yamada, Kiyoyuki. / Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 3. pp. 269-274.
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