Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga; Noriyuki Kamei; Youko Okugawa; Masaki Takagi; Atsushi Akao; Hideo Kigoshi; Kiyoyuki Yamada

doi:10.1016/S0960-894X(96)00620-8

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga, Noriyuki Kamei, Youko Okugawa, Masaki Takagi, Atsushi Akao, Hideo Kigoshi, Kiyoyuki Yamada

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

Original language	English
Pages (from-to)	269-274
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(96)00620-8
Publication status	Published - 1997 Feb 4
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(96)00620-8

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Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. / Suenaga, Kiyotake; Kamei, Noriyuki; Okugawa, Youko; Takagi, Masaki; Akao, Atsushi; Kigoshi, Hideo; Yamada, Kiyoyuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 3, 04.02.1997, p. 269-274.

Research output: Contribution to journal › Article › peer-review

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