Abstract
The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.
| Original language | English |
|---|---|
| Pages (from-to) | 269-274 |
| Number of pages | 6 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1997 Feb 4 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Suenaga, K., Kamei, N., Okugawa, Y., Takagi, M., Akao, A., Kigoshi, H., & Yamada, K. (1997). Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. Bioorganic and Medicinal Chemistry Letters, 7(3), 269-274. https://doi.org/10.1016/S0960-894X(96)00620-8