Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga; Noriyuki Kamei; Youko Okugawa; Masaki Takagi; Atsushi Akao; Hideo Kigoshi; Kiyoyuki Yamada

doi:10.1016/S0960-894X(96)00620-8

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga, Noriyuki Kamei, Youko Okugawa, Masaki Takagi, Atsushi Akao, Hideo Kigoshi, Kiyoyuki Yamada

Department of Chemistry

Research output: Contribution to journal › Article

46 Citations (Scopus)

Abstract

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

Original language	English
Pages (from-to)	269-274
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(96)00620-8
Publication status	Published - 1997 Feb 4

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ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Cite this

Suenaga, K., Kamei, N., Okugawa, Y., Takagi, M., Akao, A., Kigoshi, H., & Yamada, K. (1997). Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. Bioorganic and Medicinal Chemistry Letters, 7(3), 269-274. https://doi.org/10.1016/S0960-894X(96)00620-8

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs. / Suenaga, Kiyotake; Kamei, Noriyuki; Okugawa, Youko; Takagi, Masaki; Akao, Atsushi; Kigoshi, Hideo; Yamada, Kiyoyuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 3, 04.02.1997, p. 269-274.

Research output: Contribution to journal › Article

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10.1016/S0960-894X(96)00620-8