Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells

Taiko Oda, Noriko Ikeda, Shoko Nakashima, Yoshihiro Sato

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recently, we investigated the inhibitory effects of 17β-estradiol and diethylstilbestrol on microtubule assembly, cytotoxicity, and aneuploidy in V79 cells. The present study analyzes the effects of equilin and equilenin (amongst the natural estrogens originally isolated from the urine of pregnant horses) and their related compounds, on the relative plating efficiency of Chinese hamster V79 cells. The results showed that a hydroxyl group on 17-C and a methoxyl group on 3-C of the estrogen skeleton were important for cytotoxicity. Of the various compounds analyzed, 2-methoxyestradiol had the strongest cytotoxicity, suggesting also the importance of a methoxyl group on 2-C.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalDrug and Chemical Toxicology
Volume25
Issue number1
DOIs
Publication statusPublished - 2002 Feb 18

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

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