D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine

Shun Ichi Kimura; Hidenori Wada; Yuko Ishihara; Koji Kawamura; Kana Sakamoto; Ryoko Yamasaki; Masahiro Ashizawa; Tomohito Machishima; Miki Sato; Kiriko Terasako; Hideki Nakasone; Misato Kikuchi; Shinya Okuda; Shinichi Kako; Junya Kanda; Rie Yamazaki; Aki Tanihara; Junji Nishida; Yoshinobu Kanda

doi:10.1179/1607845413Y.0000000103

D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine

Shun Ichi Kimura, Hidenori Wada, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Ryoko Yamasaki, Masahiro Ashizawa, Tomohito Machishima, Miki Sato, Kiriko Terasako, Hideki Nakasone, Misato Kikuchi, Shinya Okuda, Shinichi Kako, Junya Kanda, Rie Yamazaki, Aki Tanihara, Junji Nishida, Yoshinobu Kanda

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The D-index is calculated as the area over the neutrophil curve during neutropenia. We investigated the impact of the D-index on pulmonary infection in 33 acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine. There was no difference in the D-index between chemotherapies with and without pulmonary infection. The cumulative D-index (c-D-index) until the development of infection exceeded 4000 in four of five patients with pulmonary infection. Although there was no difference in the total D-index throughout the overall consolidation chemotherapy, the total D-index from induction to consolidation and the D-index at induction chemotherapy were higher in patients with pulmonary infection during consolidation than in those without it (P=0.014 and 0.019, respectively). Our results showed that the cumulative effect of neutropenia might determine the risk of pulmonary infection in consolidation chemotherapy. We are planning a clinical trial of c-D-index-guided preemptive antifungal therapy.

Original language	English
Pages (from-to)	107-112
Number of pages	6
Journal	Hematology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1179/1607845413Y.0000000103
Publication status	Published - 2014 Mar
Externally published	Yes

Keywords

Acute myeloid leukemia
D-index
High-dose cytarabine
Neutropenia
Pulmonary infection

ASJC Scopus subject areas

Hematology

Access to Document

10.1179/1607845413Y.0000000103

Cite this

Kimura, S. I., Wada, H., Ishihara, Y., Kawamura, K., Sakamoto, K., Yamasaki, R., Ashizawa, M., Machishima, T., Sato, M., Terasako, K., Nakasone, H., Kikuchi, M., Okuda, S., Kako, S., Kanda, J., Yamazaki, R., Tanihara, A., Nishida, J., & Kanda, Y. (2014). D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine. Hematology, 19(2), 107-112. https://doi.org/10.1179/1607845413Y.0000000103

Kimura, SI, Wada, H, Ishihara, Y, Kawamura, K, Sakamoto, K, Yamasaki, R, Ashizawa, M, Machishima, T, Sato, M, Terasako, K, Nakasone, H, Kikuchi, M, Okuda, S, Kako, S, Kanda, J, Yamazaki, R, Tanihara, A, Nishida, J & Kanda, Y 2014, 'D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine', Hematology, vol. 19, no. 2, pp. 107-112. https://doi.org/10.1179/1607845413Y.0000000103

@article{c39eaca63ca04f20a6a2d44430633f4a,

title = "D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine",

abstract = "The D-index is calculated as the area over the neutrophil curve during neutropenia. We investigated the impact of the D-index on pulmonary infection in 33 acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine. There was no difference in the D-index between chemotherapies with and without pulmonary infection. The cumulative D-index (c-D-index) until the development of infection exceeded 4000 in four of five patients with pulmonary infection. Although there was no difference in the total D-index throughout the overall consolidation chemotherapy, the total D-index from induction to consolidation and the D-index at induction chemotherapy were higher in patients with pulmonary infection during consolidation than in those without it (P=0.014 and 0.019, respectively). Our results showed that the cumulative effect of neutropenia might determine the risk of pulmonary infection in consolidation chemotherapy. We are planning a clinical trial of c-D-index-guided preemptive antifungal therapy.",

keywords = "Acute myeloid leukemia, D-index, High-dose cytarabine, Neutropenia, Pulmonary infection",

author = "Kimura, {Shun Ichi} and Hidenori Wada and Yuko Ishihara and Koji Kawamura and Kana Sakamoto and Ryoko Yamasaki and Masahiro Ashizawa and Tomohito Machishima and Miki Sato and Kiriko Terasako and Hideki Nakasone and Misato Kikuchi and Shinya Okuda and Shinichi Kako and Junya Kanda and Rie Yamazaki and Aki Tanihara and Junji Nishida and Yoshinobu Kanda",

year = "2014",

month = mar,

doi = "10.1179/1607845413Y.0000000103",

language = "English",

volume = "19",

pages = "107--112",

journal = "Hematology",

issn = "1024-5332",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine

AU - Kimura, Shun Ichi

AU - Wada, Hidenori

AU - Ishihara, Yuko

AU - Kawamura, Koji

AU - Sakamoto, Kana

AU - Yamasaki, Ryoko

AU - Ashizawa, Masahiro

AU - Machishima, Tomohito

AU - Sato, Miki

AU - Terasako, Kiriko

AU - Nakasone, Hideki

AU - Kikuchi, Misato

AU - Okuda, Shinya

AU - Kako, Shinichi

AU - Kanda, Junya

AU - Yamazaki, Rie

AU - Tanihara, Aki

AU - Nishida, Junji

AU - Kanda, Yoshinobu

PY - 2014/3

Y1 - 2014/3

N2 - The D-index is calculated as the area over the neutrophil curve during neutropenia. We investigated the impact of the D-index on pulmonary infection in 33 acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine. There was no difference in the D-index between chemotherapies with and without pulmonary infection. The cumulative D-index (c-D-index) until the development of infection exceeded 4000 in four of five patients with pulmonary infection. Although there was no difference in the total D-index throughout the overall consolidation chemotherapy, the total D-index from induction to consolidation and the D-index at induction chemotherapy were higher in patients with pulmonary infection during consolidation than in those without it (P=0.014 and 0.019, respectively). Our results showed that the cumulative effect of neutropenia might determine the risk of pulmonary infection in consolidation chemotherapy. We are planning a clinical trial of c-D-index-guided preemptive antifungal therapy.

AB - The D-index is calculated as the area over the neutrophil curve during neutropenia. We investigated the impact of the D-index on pulmonary infection in 33 acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine. There was no difference in the D-index between chemotherapies with and without pulmonary infection. The cumulative D-index (c-D-index) until the development of infection exceeded 4000 in four of five patients with pulmonary infection. Although there was no difference in the total D-index throughout the overall consolidation chemotherapy, the total D-index from induction to consolidation and the D-index at induction chemotherapy were higher in patients with pulmonary infection during consolidation than in those without it (P=0.014 and 0.019, respectively). Our results showed that the cumulative effect of neutropenia might determine the risk of pulmonary infection in consolidation chemotherapy. We are planning a clinical trial of c-D-index-guided preemptive antifungal therapy.

KW - Acute myeloid leukemia

KW - D-index

KW - High-dose cytarabine

KW - Neutropenia

KW - Pulmonary infection

UR - http://www.scopus.com/inward/record.url?scp=84896034868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896034868&partnerID=8YFLogxK

U2 - 10.1179/1607845413Y.0000000103

DO - 10.1179/1607845413Y.0000000103

M3 - Article

C2 - 23683842

AN - SCOPUS:84896034868

SN - 1024-5332

VL - 19

SP - 107

EP - 112

JO - Hematology

JF - Hematology

IS - 2

ER -

D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this