D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia

Hiroyuki Uchida, Tarek K. Rajji, Benoit H. Mulsant, Shitij Kapur, Bruce G. Pollock, Ariel Graff-Guerrero, Mahesh Menon, David C. Mamo

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The negative impact of antipsychotic drugs on attention is expected to be greater in late-life schizophrenia because of the age-related changes in the dopamine receptor reserve. The objective of this study was to examine the relationship between dopamine D2 receptor blockade by risperidone and the cognitive function in late-life schizophrenia. Subjects with schizophrenia or schizoaffective disorder aged 50 or older who were receiving risperidone completed a [C]raclopride positron emission tomography scan to measure D2-binding potential in the striatum. The D2 receptor blockade by risperidone was calculated using age-corrected measures from healthy individuals and region of interest analysis of dynamic positron emission tomography data coregistered to the subjects' magnetic resonance imaging scans. Cognitive function was assessed using a battery of neuropsychological tests that included the Dementia Rating Scale-2 (DRS). Eleven subjects (mean ± SD age, 64 ± 8 years) participated in this study. The mean ± SD D2 receptor blockade was 69% ± 14% (range, 34%-80%). The age-corrected score on the attention subscale in the DRS was negatively correlated with the D2 receptor blockade. The DRS attention subscale score was lower in the subjects who experienced 74.9% or higher D2 blockade (median value, corresponding to a daily risperidone dose of >3.0 mg) than in those who did not. Although a causal attribution cannot be made in light of the cross-sectional nature of this study, the results suggest the critical importance of identifying the lowest effective dose of antipsychotic drugs in older patients with schizophrenia.

Original languageEnglish
Pages (from-to)571-575
Number of pages5
JournalJournal of Clinical Psychopharmacology
Volume29
Issue number6
DOIs
Publication statusPublished - 2009 Dec
Externally publishedYes

Fingerprint

Risperidone
Schizophrenia
Dementia
Positron-Emission Tomography
Cognition
Antipsychotic Agents
Raclopride
Dopamine D2 Receptors
Neuropsychological Tests
Dopamine Receptors
Psychotic Disorders
Cross-Sectional Studies
Magnetic Resonance Imaging

Keywords

  • Cognitive function
  • Dopamine
  • Elderly
  • PET
  • Risperidone
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia. / Uchida, Hiroyuki; Rajji, Tarek K.; Mulsant, Benoit H.; Kapur, Shitij; Pollock, Bruce G.; Graff-Guerrero, Ariel; Menon, Mahesh; Mamo, David C.

In: Journal of Clinical Psychopharmacology, Vol. 29, No. 6, 12.2009, p. 571-575.

Research output: Contribution to journalArticle

Uchida, H, Rajji, TK, Mulsant, BH, Kapur, S, Pollock, BG, Graff-Guerrero, A, Menon, M & Mamo, DC 2009, 'D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia', Journal of Clinical Psychopharmacology, vol. 29, no. 6, pp. 571-575. https://doi.org/10.1097/JCP.0b013e3181bf4ea3
Uchida, Hiroyuki ; Rajji, Tarek K. ; Mulsant, Benoit H. ; Kapur, Shitij ; Pollock, Bruce G. ; Graff-Guerrero, Ariel ; Menon, Mahesh ; Mamo, David C. / D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia. In: Journal of Clinical Psychopharmacology. 2009 ; Vol. 29, No. 6. pp. 571-575.
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