Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract

Ryuichi Okamoto, Tomoharu Yajima, Motomi Yamazaki, Takanori Kanai, Makio Mukai, Yasuo Ikeda, Johji Inazawa, Mamoru Watanabe

Research output: Contribution to journalArticle

336 Citations (Scopus)

Abstract

Studies have shown that bone marrow cells have the potential to differentiate into a variety of cell types. Here we show that bone marrow cells can repopulate the epithelia of the human gastrointestinal tract. Epithelial cells of male donor origin were distributed in every part of the gastrointestinal tract of female bone marrow transplant recipients. Donor-derived epithelial cells substantially repopulated the gastrointestinal tract during epithelial regeneration after graft-versus-host disease or ulcer formation. Regeneration of gastrointestinal epithelia with donor-derived cells in humans shows a potential clinical application of bone marrow-derived cells for repairing severely damaged epithelia, not only in the gastrointestinal tract but also in other tissues.

Original languageEnglish
Pages (from-to)1011-1017
Number of pages7
JournalNature medicine
Volume8
Issue number9
DOIs
Publication statusPublished - 2002 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Okamoto, R., Yajima, T., Yamazaki, M., Kanai, T., Mukai, M., Ikeda, Y., Inazawa, J., & Watanabe, M. (2002). Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nature medicine, 8(9), 1011-1017. https://doi.org/10.1038/nm755