De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: Successful treatment with autologous peripheral blood stem cell transplantation

Michihide Tokuhira, Reiko Watanabe, Atsushi Iizuka, Yasunobu Sekiguchi, Tomoe Nemoto, Kyoto Hanzawa, Ichiro Takamatsu, Taro Maruyama, Jun Ichi Tamaru, Shinji Itoyama, Hiroshi Suzuki, Tsutomu Takeuchi, Shigehisa Mori

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3 Citations (Scopus)

Abstract

Basophils play an important role in allergic inflammation and are pathologically related to hematological disturbances, such as iron deficiency anemia and myeloproliferative disorders; however, they are only rarely encountered in lymphoid malignancies. Here, we report the case of a 33-year-old man with a bulky mass of the small intestine, multiple paraaortic lymphoadenopathy, pleural effusion, and ascites, who was diagnosed as a case of de novo CD5+ diffuse large B cell lymphoma (DLBCL). This patient showed a marked elevation of the basophil count in the peripheral blood, which appeared to run in parallel with the tumor burden. High dose chemotherapy followed by autologous peripheral blood cell transplantation yielded complete remission, and the patient has remained disease free for 5 years. To the best of our knowledge, this is the first report of a case of de novo CD5+ DLBCL showing marked elevation of the PB basophil count.

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalAmerican journal of hematology
Volume82
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1

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Keywords

  • Autologous peripheral blood stem cell transplantation
  • Basophilia
  • CD5
  • Diffuse large B cell lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

Tokuhira, M., Watanabe, R., Iizuka, A., Sekiguchi, Y., Nemoto, T., Hanzawa, K., Takamatsu, I., Maruyama, T., Tamaru, J. I., Itoyama, S., Suzuki, H., Takeuchi, T., & Mori, S. (2007). De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: Successful treatment with autologous peripheral blood stem cell transplantation. American journal of hematology, 82(2), 162-167. https://doi.org/10.1002/ajh.20786