De novo development of moyamoya disease in an adult female: Case report

Raita Fukaya, Kazunari Yoshida, Takenori Akiyama, Takeshi Kawase

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The origin of moyamoya disease remains unknown. The onset of the angiographically apparent changes of typical moyamoya disease occurs in childhood, but de novo development of the disease has not been confirmed angiographically. The authors report on a case of de novo development of moyamoya disease in a middle-aged female whose cerebral angiography demonstrated no abnormal findings 5 years previously. To the best of the authors' knowledge, this case is the first reported instance of de novo development of definite moyamoya disease verified angiographically. This case demonstrates that the de novo development of moyamoya disease in a middle-aged adult did in fact occur, and angiographically visible features of the disease took < 5 years to complete.

Original languageEnglish
Pages (from-to)943-946
Number of pages4
JournalJournal of neurosurgery
Issue number5
Publication statusPublished - 2009 Jan 1



  • Adult
  • Angiography
  • De novo development
  • Moyamoya disease

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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