De novo NSF mutations cause early infantile epileptic encephalopathy

Hisato Suzuki, Takeshi Yoshida, Naoya Morisada, Tomoko Uehara, Kenjiro Kosaki, Katsunori Sato, Kohei Matsubara, Toshiyuki Takano-Shimizu, Toshiki Takenouchi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


N-ethylmaleimide-sensitive factor (NSF) plays a critical role in intracellular vesicle transport, which is essential for neurotransmitter release. Herein, we, for the first time, document human monogenic disease phenotype of de novo pathogenic variants in NSF, that is, epileptic encephalopathy of early infantile onset. When expressed in the developing eye of Drosophila, the mutant NSF severely affected eye development, while the wild-type allele had no detectable effect under the same conditions. Our findings suggest that the two pathogenic variants exert a dominant negative effect. De novo heterozygous mutations in the NSF gene cause early infantile epileptic encephalopathy.

Original languageEnglish
Pages (from-to)2334-2339
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Issue number11
Publication statusPublished - 2019 Nov 1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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