Decision making in Parkinson's disease: Analysis of behavioral and physiological patterns in the Iowa Gambling task

Mutsutaka Kobayakawa, Shinichi Koyama, Masaru Mimura, Mitsuru Kawamura

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Recent studies suggest that social recognition processes are affected by Parkinson's disease (PD). However, whether PD patients exhibit behavioral changes is still controversial. The purpose of the present study was to examine the decision making of PD patients performing the Iowa Gambling Task (IGT). We recruited a large number of early, nondemented PD patients for the IGT. We also recorded the skin conductance responses (SCRs) during the task as a measure of emotional arousal. Compared with the normal control (NC) subjects, PD patients selected more disadvantageous decks in the IGT, and their SCRs were lower than those of NC subjects before making decisions and after receiving reward or punishment. The tendency toward risky choices was not correlated with age, education, global cognitive function, or the severity of the disease. These results confirmed that the decision making of PD patients was affected by the disease, rather than by other cognitive functions; moreover, such behavior was related to lower emotional responses. Behavioral and SCR patterns of PD patients were similar to those of amygdala-damaged patients. The response bias toward risky choices in PD may be explained by the dysfunction of the amygdala, which is known to be involved in risk evaluation.

Original languageEnglish
Pages (from-to)547-552
Number of pages6
JournalMovement Disorders
Volume23
Issue number4
DOIs
Publication statusPublished - 2008 Mar 15
Externally publishedYes

Fingerprint

Gambling
Parkinson Disease
Decision Making
Amygdala
Cognition
Skin
Punishment
Arousal
Reward
Education

Keywords

  • Decision-making
  • Iowa gambling task
  • Parkinson's disease
  • Skin conductance response
  • Social cognition

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Decision making in Parkinson's disease : Analysis of behavioral and physiological patterns in the Iowa Gambling task. / Kobayakawa, Mutsutaka; Koyama, Shinichi; Mimura, Masaru; Kawamura, Mitsuru.

In: Movement Disorders, Vol. 23, No. 4, 15.03.2008, p. 547-552.

Research output: Contribution to journalArticle

Kobayakawa, Mutsutaka ; Koyama, Shinichi ; Mimura, Masaru ; Kawamura, Mitsuru. / Decision making in Parkinson's disease : Analysis of behavioral and physiological patterns in the Iowa Gambling task. In: Movement Disorders. 2008 ; Vol. 23, No. 4. pp. 547-552.
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