Decline in FEV1 in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid

Tomoko Betsuyaku, Masaharu Nishimura, Kimihiro Takeyabu, Mishie Tanino, Kenji Miyamoto, Yoshikazu Kawakami

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Neutrophil elastase (NE) is thought to be one of the key proteinases in the development of chronic obstructive pulmonary disease (COPD). Previously, we have shown that the NE-α1-proteinase inhibitor (NE-α1PI) complex in bronchoalveolar lavage (BAL) fluid was markedly elevated in asymptomatic smokers who had subclinical emphysema on CT scans. We proposed that excessive NE-α1PI complex in BAL fluid was a factor which might differentiate smokers who were developing emphysema from others. Objective: In this study, we addressed the question of whether elevated levels of the NE-α1PI complex in BAL fluid are linked to the accelerated decline in pulmonary functions in those subjects. Methods: We conducted a follow-up study to analyze the decline in FEV1 for 4.3 years on average for 26 community-based volunteers who had received pulmonary function tests, CT scans and BAL. The levels of the NE-α1PI complex in BAL fluid and in plasma was measured. Results: Neither pulmonary function measurements nor the presence of emphysema on CT scans could predict the decline in FEV1. The number of inflammatory cells in BAL fluid was also not an indicator of progression. By contrast, subjects with higher levels of the NE-α1PI complex in BAL fluid had a significantly accelerated decline in FEV1 compared to those with lower levels. Conclusion: These data seem to support the hypothesis that NE in the lung is related to the onset and/or progression of COPD. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalRespiration
Volume67
Issue number3
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Leukocyte Elastase
Bronchoalveolar Lavage Fluid
Volunteers
Emphysema
Lung
Chronic Obstructive Pulmonary Disease
Peptide Hydrolases
Respiratory Function Tests
Bronchoalveolar Lavage
Cell Count

Keywords

  • Bronchoalveolar lavage
  • Chronic obstructive pulmonary disease
  • Computed tomography
  • FEV, annual decline
  • Neutrophil elastase

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Betsuyaku, T., Nishimura, M., Takeyabu, K., Tanino, M., Miyamoto, K., & Kawakami, Y. (2000). Decline in FEV1 in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid. Respiration, 67(3), 261-267.

Decline in FEV1 in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid. / Betsuyaku, Tomoko; Nishimura, Masaharu; Takeyabu, Kimihiro; Tanino, Mishie; Miyamoto, Kenji; Kawakami, Yoshikazu.

In: Respiration, Vol. 67, No. 3, 2000, p. 261-267.

Research output: Contribution to journalArticle

Betsuyaku, T, Nishimura, M, Takeyabu, K, Tanino, M, Miyamoto, K & Kawakami, Y 2000, 'Decline in FEV1 in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid', Respiration, vol. 67, no. 3, pp. 261-267.
Betsuyaku T, Nishimura M, Takeyabu K, Tanino M, Miyamoto K, Kawakami Y. Decline in FEV1 in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid. Respiration. 2000;67(3):261-267.
Betsuyaku, Tomoko ; Nishimura, Masaharu ; Takeyabu, Kimihiro ; Tanino, Mishie ; Miyamoto, Kenji ; Kawakami, Yoshikazu. / Decline in FEV1 in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid. In: Respiration. 2000 ; Vol. 67, No. 3. pp. 261-267.
@article{d22dfd25658e44869cde762ef0ebd860,
title = "Decline in FEV1 in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid",
abstract = "Background: Neutrophil elastase (NE) is thought to be one of the key proteinases in the development of chronic obstructive pulmonary disease (COPD). Previously, we have shown that the NE-α1-proteinase inhibitor (NE-α1PI) complex in bronchoalveolar lavage (BAL) fluid was markedly elevated in asymptomatic smokers who had subclinical emphysema on CT scans. We proposed that excessive NE-α1PI complex in BAL fluid was a factor which might differentiate smokers who were developing emphysema from others. Objective: In this study, we addressed the question of whether elevated levels of the NE-α1PI complex in BAL fluid are linked to the accelerated decline in pulmonary functions in those subjects. Methods: We conducted a follow-up study to analyze the decline in FEV1 for 4.3 years on average for 26 community-based volunteers who had received pulmonary function tests, CT scans and BAL. The levels of the NE-α1PI complex in BAL fluid and in plasma was measured. Results: Neither pulmonary function measurements nor the presence of emphysema on CT scans could predict the decline in FEV1. The number of inflammatory cells in BAL fluid was also not an indicator of progression. By contrast, subjects with higher levels of the NE-α1PI complex in BAL fluid had a significantly accelerated decline in FEV1 compared to those with lower levels. Conclusion: These data seem to support the hypothesis that NE in the lung is related to the onset and/or progression of COPD. Copyright (C) 2000 S. Karger AG, Basel.",
keywords = "Bronchoalveolar lavage, Chronic obstructive pulmonary disease, Computed tomography, FEV, annual decline, Neutrophil elastase",
author = "Tomoko Betsuyaku and Masaharu Nishimura and Kimihiro Takeyabu and Mishie Tanino and Kenji Miyamoto and Yoshikazu Kawakami",
year = "2000",
language = "English",
volume = "67",
pages = "261--267",
journal = "Respiration; international review of thoracic diseases",
issn = "0025-7931",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Decline in FEV1 in community-based older volunteers with higher levels of neutrophil elastase in bronchoalveolar lavage fluid

AU - Betsuyaku, Tomoko

AU - Nishimura, Masaharu

AU - Takeyabu, Kimihiro

AU - Tanino, Mishie

AU - Miyamoto, Kenji

AU - Kawakami, Yoshikazu

PY - 2000

Y1 - 2000

N2 - Background: Neutrophil elastase (NE) is thought to be one of the key proteinases in the development of chronic obstructive pulmonary disease (COPD). Previously, we have shown that the NE-α1-proteinase inhibitor (NE-α1PI) complex in bronchoalveolar lavage (BAL) fluid was markedly elevated in asymptomatic smokers who had subclinical emphysema on CT scans. We proposed that excessive NE-α1PI complex in BAL fluid was a factor which might differentiate smokers who were developing emphysema from others. Objective: In this study, we addressed the question of whether elevated levels of the NE-α1PI complex in BAL fluid are linked to the accelerated decline in pulmonary functions in those subjects. Methods: We conducted a follow-up study to analyze the decline in FEV1 for 4.3 years on average for 26 community-based volunteers who had received pulmonary function tests, CT scans and BAL. The levels of the NE-α1PI complex in BAL fluid and in plasma was measured. Results: Neither pulmonary function measurements nor the presence of emphysema on CT scans could predict the decline in FEV1. The number of inflammatory cells in BAL fluid was also not an indicator of progression. By contrast, subjects with higher levels of the NE-α1PI complex in BAL fluid had a significantly accelerated decline in FEV1 compared to those with lower levels. Conclusion: These data seem to support the hypothesis that NE in the lung is related to the onset and/or progression of COPD. Copyright (C) 2000 S. Karger AG, Basel.

AB - Background: Neutrophil elastase (NE) is thought to be one of the key proteinases in the development of chronic obstructive pulmonary disease (COPD). Previously, we have shown that the NE-α1-proteinase inhibitor (NE-α1PI) complex in bronchoalveolar lavage (BAL) fluid was markedly elevated in asymptomatic smokers who had subclinical emphysema on CT scans. We proposed that excessive NE-α1PI complex in BAL fluid was a factor which might differentiate smokers who were developing emphysema from others. Objective: In this study, we addressed the question of whether elevated levels of the NE-α1PI complex in BAL fluid are linked to the accelerated decline in pulmonary functions in those subjects. Methods: We conducted a follow-up study to analyze the decline in FEV1 for 4.3 years on average for 26 community-based volunteers who had received pulmonary function tests, CT scans and BAL. The levels of the NE-α1PI complex in BAL fluid and in plasma was measured. Results: Neither pulmonary function measurements nor the presence of emphysema on CT scans could predict the decline in FEV1. The number of inflammatory cells in BAL fluid was also not an indicator of progression. By contrast, subjects with higher levels of the NE-α1PI complex in BAL fluid had a significantly accelerated decline in FEV1 compared to those with lower levels. Conclusion: These data seem to support the hypothesis that NE in the lung is related to the onset and/or progression of COPD. Copyright (C) 2000 S. Karger AG, Basel.

KW - Bronchoalveolar lavage

KW - Chronic obstructive pulmonary disease

KW - Computed tomography

KW - FEV, annual decline

KW - Neutrophil elastase

UR - http://www.scopus.com/inward/record.url?scp=0034127686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034127686&partnerID=8YFLogxK

M3 - Article

VL - 67

SP - 261

EP - 267

JO - Respiration; international review of thoracic diseases

JF - Respiration; international review of thoracic diseases

SN - 0025-7931

IS - 3

ER -