Decrease by psychotropic drugs and local anaesthetics of membrane fluidity measured by fluorescence anisotropy in Escherichia coli

K. Tanji, Y. Ohta, S. Kawato, T. Mizushima, S. Natori, K. Sekimizu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effects of psychotropic drugs and local anaesthetics on the fluidity of Escherichia coli cell membranes were examined. Chlorpromazine was shown to increase 1,6-diphenyl-1,3,5-hexatriene fluorescence anisotropy, indicating that it decreased the membrane fluidity. This increase was significant at a temperature of more than 24°C. Dibucaine, lignocaine, imipramine, tetracaine and procaine also increased the fluorescence anisotropy.

Original languageEnglish
Pages (from-to)1036-1037
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume44
Issue number12
Publication statusPublished - 1992 Jan 1

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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