Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption

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3 Citations (Scopus)

Abstract

The drug interaction between new quinolone antibiotics (NQs) and polyvalent metal cation products, leading to a significant decrease in the absorption of NQ, is considered to be attributable to the formation of poorly absorbable chelate and physicochemical adsorption of NQs to cation products. To clarify the mechanisms of this drug interaction in detail, we investigated the effects of Al3+ or Mg2+ on the membrane permeation profile of ciprofloxacin (CPFX) across human colon carcinoma cell lines (Caco-2) in monolayer culture, and characterized the adsorption nature of CPFX to polyvalent metal cation products under physiological conditions. As a result, Al3+ or Mg2+ partially but not fully impaired the permeation of CPFX across Caco-2 monolayer up to 30% or 60% of control, respectively. Physicochemical adsorption of CPFX to cation products was not observed under physiological pH. In conclusion, two possible mechanisms investigated, the decrease in the permeability of CPFX by chelate formation and adsorption of CPFX to polyvalent metal cation products, may partially but not fully explain the extent of the drug interaction clinically observed.

Original languageEnglish
Pages (from-to)414-418
Number of pages5
JournalDrug Metabolism and Pharmacokinetics
Volume29
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Ciprofloxacin
Adsorption
Cations
Metals
Drug Interactions
Quinolones
Permeability
Colon
Anti-Bacterial Agents
Carcinoma
Cell Line
Membranes

Keywords

  • Absorption
  • Adsorption
  • Aluminum
  • Caco-2 cells
  • Chelate
  • Drug interactions
  • Magnesium
  • New quinolones
  • Permeability

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmaceutical Science

Cite this

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title = "Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption",
abstract = "The drug interaction between new quinolone antibiotics (NQs) and polyvalent metal cation products, leading to a significant decrease in the absorption of NQ, is considered to be attributable to the formation of poorly absorbable chelate and physicochemical adsorption of NQs to cation products. To clarify the mechanisms of this drug interaction in detail, we investigated the effects of Al3+ or Mg2+ on the membrane permeation profile of ciprofloxacin (CPFX) across human colon carcinoma cell lines (Caco-2) in monolayer culture, and characterized the adsorption nature of CPFX to polyvalent metal cation products under physiological conditions. As a result, Al3+ or Mg2+ partially but not fully impaired the permeation of CPFX across Caco-2 monolayer up to 30{\%} or 60{\%} of control, respectively. Physicochemical adsorption of CPFX to cation products was not observed under physiological pH. In conclusion, two possible mechanisms investigated, the decrease in the permeability of CPFX by chelate formation and adsorption of CPFX to polyvalent metal cation products, may partially but not fully explain the extent of the drug interaction clinically observed.",
keywords = "Absorption, Adsorption, Aluminum, Caco-2 cells, Chelate, Drug interactions, Magnesium, New quinolones, Permeability",
author = "Ayuko Imaoka and Michiko Hattori and Takeshi Akiyoshi and Hisakazu Ohtani",
year = "2014",
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language = "English",
volume = "29",
pages = "414--418",
journal = "Drug Metabolism and Pharmacokinetics",
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AU - Imaoka, Ayuko

AU - Hattori, Michiko

AU - Akiyoshi, Takeshi

AU - Ohtani, Hisakazu

PY - 2014

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AB - The drug interaction between new quinolone antibiotics (NQs) and polyvalent metal cation products, leading to a significant decrease in the absorption of NQ, is considered to be attributable to the formation of poorly absorbable chelate and physicochemical adsorption of NQs to cation products. To clarify the mechanisms of this drug interaction in detail, we investigated the effects of Al3+ or Mg2+ on the membrane permeation profile of ciprofloxacin (CPFX) across human colon carcinoma cell lines (Caco-2) in monolayer culture, and characterized the adsorption nature of CPFX to polyvalent metal cation products under physiological conditions. As a result, Al3+ or Mg2+ partially but not fully impaired the permeation of CPFX across Caco-2 monolayer up to 30% or 60% of control, respectively. Physicochemical adsorption of CPFX to cation products was not observed under physiological pH. In conclusion, two possible mechanisms investigated, the decrease in the permeability of CPFX by chelate formation and adsorption of CPFX to polyvalent metal cation products, may partially but not fully explain the extent of the drug interaction clinically observed.

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