Decrease in glomerular filtration rate by plasma low-density lipoprotein cholesterol in subjects with normal kidney function assessed by urinalysis and plasma creatinine

Yasuko Morita, Yasuhiko Homma, Mihoko Igarashi, Ryuusuke Miyano, Hiroshi Yamaguchi, Momoo Matsuda, Toshimori Tanigaki, Yutaka Shiina, Koichiro Honma

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: It has not been well defined whether plasma low-density lipoprotein cholesterol (LDL-C) progresses arteriolosclerosis (arteriosclerosis of small arteries) or not. Estimated glomerular filtration rate (e-GFR) is an indicator of the function of renal arterioles and capillaries of glomeruli. The relationship between e-GFR and plasma LDL-C was studied to estimate the effect of plasma LDL-C on the function of renal arterioles and capillaries of glomeruli to speculate the effect of plasma LDL-C on arteriolosclerosis. Methods and results: Major coronary risk factors; blood pressure, plasma lipids, and fasting plasma glucose were compared among 4 groups of examinees of a health evaluation and promotion center separated by e-GFR, namely, Control group, Group 1, 2, 3 from highest e-GFR to lowest e-GFR. Numbers of total male and female subjects were 4602 and 2920, respectively. Plasma LDL-C levels were significantly high in Group 2 and 3 in all male subjects and high in Group 1, 2, and 3 in male subjects with age of fifties, compared with Control group. Plasma LDL-C levels were significantly high in Group 1, 2, and 3 in all female subjects and high in Group 2 and 3 in female subjects with age of fifties, compared with Control group. Plasma levels of LDL-C were not significantly different at each years of age in subjects with age of fifties in both sex. BMI and waist circumference were higher in male subjects with low e-GFR but not in female subjects. Blood pressure and fasting plasma glucose were not high in subjects in Group 1, 2, and 3, compared with Control group in all subjects and subjects with age of fifties in both sex. Conclusions: We concluded that the high plasma level of LDL-C was the major risk factor among coronary risk factors to reduce GFR probably due to impairing the function of renal arterioles and capillaries of glomeruli in subjects with normal kidney function assessed by urinalysis and plasma creatinine.

Original languageEnglish
Pages (from-to)602-606
Number of pages5
JournalAtherosclerosis
Volume210
Issue number2
DOIs
Publication statusPublished - 2010 Jun

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Urinalysis
Glomerular Filtration Rate
LDL Cholesterol
Creatinine
Kidney
Arteriolosclerosis
Arterioles
Control Groups
Fasting
Blood Pressure
Glucose
Arteriosclerosis
Waist Circumference
Health Promotion
Arteries

Keywords

  • Blood pressure
  • Coronary risk factors
  • E-GFR
  • LDL cholesterol
  • Plasma glucose

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Decrease in glomerular filtration rate by plasma low-density lipoprotein cholesterol in subjects with normal kidney function assessed by urinalysis and plasma creatinine. / Morita, Yasuko; Homma, Yasuhiko; Igarashi, Mihoko; Miyano, Ryuusuke; Yamaguchi, Hiroshi; Matsuda, Momoo; Tanigaki, Toshimori; Shiina, Yutaka; Honma, Koichiro.

In: Atherosclerosis, Vol. 210, No. 2, 06.2010, p. 602-606.

Research output: Contribution to journalArticle

Morita, Yasuko ; Homma, Yasuhiko ; Igarashi, Mihoko ; Miyano, Ryuusuke ; Yamaguchi, Hiroshi ; Matsuda, Momoo ; Tanigaki, Toshimori ; Shiina, Yutaka ; Honma, Koichiro. / Decrease in glomerular filtration rate by plasma low-density lipoprotein cholesterol in subjects with normal kidney function assessed by urinalysis and plasma creatinine. In: Atherosclerosis. 2010 ; Vol. 210, No. 2. pp. 602-606.
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AU - Homma, Yasuhiko

AU - Igarashi, Mihoko

AU - Miyano, Ryuusuke

AU - Yamaguchi, Hiroshi

AU - Matsuda, Momoo

AU - Tanigaki, Toshimori

AU - Shiina, Yutaka

AU - Honma, Koichiro

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AB - Objective: It has not been well defined whether plasma low-density lipoprotein cholesterol (LDL-C) progresses arteriolosclerosis (arteriosclerosis of small arteries) or not. Estimated glomerular filtration rate (e-GFR) is an indicator of the function of renal arterioles and capillaries of glomeruli. The relationship between e-GFR and plasma LDL-C was studied to estimate the effect of plasma LDL-C on the function of renal arterioles and capillaries of glomeruli to speculate the effect of plasma LDL-C on arteriolosclerosis. Methods and results: Major coronary risk factors; blood pressure, plasma lipids, and fasting plasma glucose were compared among 4 groups of examinees of a health evaluation and promotion center separated by e-GFR, namely, Control group, Group 1, 2, 3 from highest e-GFR to lowest e-GFR. Numbers of total male and female subjects were 4602 and 2920, respectively. Plasma LDL-C levels were significantly high in Group 2 and 3 in all male subjects and high in Group 1, 2, and 3 in male subjects with age of fifties, compared with Control group. Plasma LDL-C levels were significantly high in Group 1, 2, and 3 in all female subjects and high in Group 2 and 3 in female subjects with age of fifties, compared with Control group. Plasma levels of LDL-C were not significantly different at each years of age in subjects with age of fifties in both sex. BMI and waist circumference were higher in male subjects with low e-GFR but not in female subjects. Blood pressure and fasting plasma glucose were not high in subjects in Group 1, 2, and 3, compared with Control group in all subjects and subjects with age of fifties in both sex. Conclusions: We concluded that the high plasma level of LDL-C was the major risk factor among coronary risk factors to reduce GFR probably due to impairing the function of renal arterioles and capillaries of glomeruli in subjects with normal kidney function assessed by urinalysis and plasma creatinine.

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KW - Coronary risk factors

KW - E-GFR

KW - LDL cholesterol

KW - Plasma glucose

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