Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction

Tsunehisa Yamamoto, Jin Endo, Masaharu Kataoka, Tomohiro Matsuhashi, Yoshinori Katsumata, Kosuke Shirakawa, Naohiro Yoshida, Sarasa Isobe, Hidenori Moriyama, Shinichi Goto, Kaoru Yamashita, Hiroki Nakanishi, Yuta Shimanaka, Nozomu Kono, Ken Shinmura, Hiroyuki Arai, Keiichi Fukuda, Motoaki Sano

Research output: Contribution to journalArticle

Abstract

Increase in saturated fatty acid (SFA) content in membrane phospholipids dramatically affects membrane properties and cellular functioning. We sought to determine whether exogenous SFA from the diet directly affects the degree of membrane phospholipid unsaturation in adult hearts and if these changes correlate with contractile dysfunction. Although both SFA-rich high fat diets (HFDs) and monounsaturated FA (MUFA)-rich HFDs cause the same degree of activation of myocardial FA uptake, triglyceride turnover, and mitochondrial FA oxidation and accumulation of toxic lipid intermediates, the former induced more severe diastolic dysfunction than the latter, which was accompanied with a decrease in membrane phospholipid unsaturation, induction of unfolded protein response (UPR), and a decrease in the expression of Sirt1 and stearoyl-CoA desaturase-1 (SCD1), catalyzing the conversion of SFA to MUFA. When the SFA supply in the heart overwhelms the cellular capacity to use it for energy, excess exogenous SFA channels to membrane phospholipids, leading to UPR induction, and development of diastolic dysfunction.

Original languageEnglish
Article numbere0208396
JournalPLoS One
Volume13
Issue number12
DOIs
Publication statusPublished - 2018 Dec 1

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saturated fatty acids
Phospholipids
phospholipids
Fatty Acids
Membranes
Nutrition
unfolded protein response
Unfolded Protein Response
High Fat Diet
high fat diet
Fats
heart
Stearoyl-CoA Desaturase
Mitochondrial Turnover
stearoyl-CoA desaturase
Poisons
Ion Channels
Triglycerides
Proteins
Chemical activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction. / Yamamoto, Tsunehisa; Endo, Jin; Kataoka, Masaharu; Matsuhashi, Tomohiro; Katsumata, Yoshinori; Shirakawa, Kosuke; Yoshida, Naohiro; Isobe, Sarasa; Moriyama, Hidenori; Goto, Shinichi; Yamashita, Kaoru; Nakanishi, Hiroki; Shimanaka, Yuta; Kono, Nozomu; Shinmura, Ken; Arai, Hiroyuki; Fukuda, Keiichi; Sano, Motoaki.

In: PLoS One, Vol. 13, No. 12, e0208396, 01.12.2018.

Research output: Contribution to journalArticle

Yamamoto, T, Endo, J, Kataoka, M, Matsuhashi, T, Katsumata, Y, Shirakawa, K, Yoshida, N, Isobe, S, Moriyama, H, Goto, S, Yamashita, K, Nakanishi, H, Shimanaka, Y, Kono, N, Shinmura, K, Arai, H, Fukuda, K & Sano, M 2018, 'Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction', PLoS One, vol. 13, no. 12, e0208396. https://doi.org/10.1371/journal.pone.0208396
Yamamoto, Tsunehisa ; Endo, Jin ; Kataoka, Masaharu ; Matsuhashi, Tomohiro ; Katsumata, Yoshinori ; Shirakawa, Kosuke ; Yoshida, Naohiro ; Isobe, Sarasa ; Moriyama, Hidenori ; Goto, Shinichi ; Yamashita, Kaoru ; Nakanishi, Hiroki ; Shimanaka, Yuta ; Kono, Nozomu ; Shinmura, Ken ; Arai, Hiroyuki ; Fukuda, Keiichi ; Sano, Motoaki. / Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction. In: PLoS One. 2018 ; Vol. 13, No. 12.
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