Decrease in vascular endothelial growth factor expression area in islets may be associated with type 2 diabetes development

Yoshihiro Takamiya, Yoichi Oikawa, Taketo Yamada, Akira Shimada, Hiroshi Itoh

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Aims: Animal studies have demonstrated that decreased vessel density in islets due to reduced expression of islet vascular endothelial growth factor (VEGF) may lead to impaired insulin secretion from β-cells, possibly contributing to type 2 diabetes development. However, no study has demonstrated an association between VEGF expression and vessel density in islets in human subjects with type 2 diabetes. The aim of this study was to evaluate the role of VEGF expression in islets in type 2 diabetes development, using human pancreatic tissue. Methods: We collected pancreatic tissue at autopsy from type 2 diabetic subjects (n = 13) and age- and sex-matched nondiabetic subjects (n = 13) under 80 years old, and investigated VEGF expression area and vessel density in islets by immunohistochemical staining. Results: In comparison with nondiabetic subjects, type 2 diabetic subjects showed a decrease in both islet VEGF expression area and islet vessel density, which were positively correlated in all subjects examined and in type 2 diabetic subjects. Conclusions: Decreased islet VEGF expression may be associated with the decrease in islet vessel volume, which probably contributes to type 2 diabetes development due to impaired insulin secretion from β-cells.

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalDiabetology International
Volume3
Issue number4
DOIs
Publication statusPublished - 2012 Dec 1

Keywords

  • Islet
  • Type 2 diabetes
  • Vascular endothelial growth factor (VEGF)
  • Vessel density

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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