Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer

Hiroyuki Ozawa, Tatsuo Matsunaga, Kazusaku Kamiya, Yutaka Tokumaru, Masato Fujii, Toshiki Tomita, Kaoru Ogawa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The relation of connexins and carcinogenesis has been studied in various organs and cell lines, with connexins currently being considered tumor suppressors. Materials and Methods: The expression of connexin-26 (Cx26) and connexin-30 (Cx30) in human head and neck carcinomas, as well as in adjacent normal mucosa, was evaluated by immunohistochemistry. Furthermore, the expression of these connexins with regard to apoptosis and cell differentiation was investigated. Results: In the cancer tissues, Cx30 expression was drastically reduced compared to apparently normal mucosa while Cx26 expression was almost the same. The intracellular distribution patterns of Cx26 and Cx30 in cancer cells differed between cancer locations. In the cancer tissues, expression of Cx26 and Cx30 was not related to apoptosis assessed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) reaction or to cell differentiation assessed by immunoreaction to involucrin. Conclusion: The present results suggest that connexins may play a role in the carcinogenesis of head and neck cancer.

Original languageEnglish
Pages (from-to)2189-2195
Number of pages7
JournalAnticancer Research
Volume27
Issue number4 B
Publication statusPublished - 2007 Jul

Fingerprint

Connexins
Head and Neck Neoplasms
Neoplasms
Cell Differentiation
Carcinogenesis
Mucous Membrane
Apoptosis
Connexin 26
Biotin
Neck
Immunohistochemistry
Head
Carcinoma
Cell Line

Keywords

  • Connexin 26
  • Connexin 30
  • Head and neck cancer
  • Tumor suppressor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ozawa, H., Matsunaga, T., Kamiya, K., Tokumaru, Y., Fujii, M., Tomita, T., & Ogawa, K. (2007). Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer. Anticancer Research, 27(4 B), 2189-2195.

Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer. / Ozawa, Hiroyuki; Matsunaga, Tatsuo; Kamiya, Kazusaku; Tokumaru, Yutaka; Fujii, Masato; Tomita, Toshiki; Ogawa, Kaoru.

In: Anticancer Research, Vol. 27, No. 4 B, 07.2007, p. 2189-2195.

Research output: Contribution to journalArticle

Ozawa, H, Matsunaga, T, Kamiya, K, Tokumaru, Y, Fujii, M, Tomita, T & Ogawa, K 2007, 'Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer', Anticancer Research, vol. 27, no. 4 B, pp. 2189-2195.
Ozawa H, Matsunaga T, Kamiya K, Tokumaru Y, Fujii M, Tomita T et al. Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer. Anticancer Research. 2007 Jul;27(4 B):2189-2195.
Ozawa, Hiroyuki ; Matsunaga, Tatsuo ; Kamiya, Kazusaku ; Tokumaru, Yutaka ; Fujii, Masato ; Tomita, Toshiki ; Ogawa, Kaoru. / Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer. In: Anticancer Research. 2007 ; Vol. 27, No. 4 B. pp. 2189-2195.
@article{5cee46e4ddd9498fa09cb93778404353,
title = "Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer",
abstract = "Background: The relation of connexins and carcinogenesis has been studied in various organs and cell lines, with connexins currently being considered tumor suppressors. Materials and Methods: The expression of connexin-26 (Cx26) and connexin-30 (Cx30) in human head and neck carcinomas, as well as in adjacent normal mucosa, was evaluated by immunohistochemistry. Furthermore, the expression of these connexins with regard to apoptosis and cell differentiation was investigated. Results: In the cancer tissues, Cx30 expression was drastically reduced compared to apparently normal mucosa while Cx26 expression was almost the same. The intracellular distribution patterns of Cx26 and Cx30 in cancer cells differed between cancer locations. In the cancer tissues, expression of Cx26 and Cx30 was not related to apoptosis assessed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) reaction or to cell differentiation assessed by immunoreaction to involucrin. Conclusion: The present results suggest that connexins may play a role in the carcinogenesis of head and neck cancer.",
keywords = "Connexin 26, Connexin 30, Head and neck cancer, Tumor suppressor",
author = "Hiroyuki Ozawa and Tatsuo Matsunaga and Kazusaku Kamiya and Yutaka Tokumaru and Masato Fujii and Toshiki Tomita and Kaoru Ogawa",
year = "2007",
month = "7",
language = "English",
volume = "27",
pages = "2189--2195",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4 B",

}

TY - JOUR

T1 - Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head and neck cancer

AU - Ozawa, Hiroyuki

AU - Matsunaga, Tatsuo

AU - Kamiya, Kazusaku

AU - Tokumaru, Yutaka

AU - Fujii, Masato

AU - Tomita, Toshiki

AU - Ogawa, Kaoru

PY - 2007/7

Y1 - 2007/7

N2 - Background: The relation of connexins and carcinogenesis has been studied in various organs and cell lines, with connexins currently being considered tumor suppressors. Materials and Methods: The expression of connexin-26 (Cx26) and connexin-30 (Cx30) in human head and neck carcinomas, as well as in adjacent normal mucosa, was evaluated by immunohistochemistry. Furthermore, the expression of these connexins with regard to apoptosis and cell differentiation was investigated. Results: In the cancer tissues, Cx30 expression was drastically reduced compared to apparently normal mucosa while Cx26 expression was almost the same. The intracellular distribution patterns of Cx26 and Cx30 in cancer cells differed between cancer locations. In the cancer tissues, expression of Cx26 and Cx30 was not related to apoptosis assessed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) reaction or to cell differentiation assessed by immunoreaction to involucrin. Conclusion: The present results suggest that connexins may play a role in the carcinogenesis of head and neck cancer.

AB - Background: The relation of connexins and carcinogenesis has been studied in various organs and cell lines, with connexins currently being considered tumor suppressors. Materials and Methods: The expression of connexin-26 (Cx26) and connexin-30 (Cx30) in human head and neck carcinomas, as well as in adjacent normal mucosa, was evaluated by immunohistochemistry. Furthermore, the expression of these connexins with regard to apoptosis and cell differentiation was investigated. Results: In the cancer tissues, Cx30 expression was drastically reduced compared to apparently normal mucosa while Cx26 expression was almost the same. The intracellular distribution patterns of Cx26 and Cx30 in cancer cells differed between cancer locations. In the cancer tissues, expression of Cx26 and Cx30 was not related to apoptosis assessed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) reaction or to cell differentiation assessed by immunoreaction to involucrin. Conclusion: The present results suggest that connexins may play a role in the carcinogenesis of head and neck cancer.

KW - Connexin 26

KW - Connexin 30

KW - Head and neck cancer

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=34547824547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547824547&partnerID=8YFLogxK

M3 - Article

C2 - 17695503

AN - SCOPUS:34547824547

VL - 27

SP - 2189

EP - 2195

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 4 B

ER -