Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification

Yukari Atsumi; Hiroshi Sakakibara; Yoshihiko Morikawa; Koichi Miyata; Hiroyuki Yamagishi; Masahiro Misawa; Masaru Miura

doi:10.1007/s12519-020-00385-x

Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification

Yukari Atsumi, Hiroshi Sakakibara, Yoshihiko Morikawa, Koichi Miyata, Hiroyuki Yamagishi, Masahiro Misawa, Masaru Miura

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Although Kawasaki disease (KD) is known to cause anemia, the relationship between its prognosis and hemoglobin level is less well known. Methods: We herein performed a secondary analysis of data from a previous study (Post-RAISE). Children aged 6 months to 2 years at the time of KD diagnosis were enrolled. Decreased hemoglobin was defined as a decrease > 10% on post-treatment day 2 compared with the level prior to the initial therapy. Results: Of 1253 KD cases, treatment resistance was observed in 209 (17%) and was significantly more frequent in the decreased hemoglobin group (37/167 vs. 172/1086, P = 0.041). Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment (odds ratio 1.53; 95% confidence interval 1.00–2.33; P = 0.048). Conclusions: Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

Original language	English
Pages (from-to)	623-628
Number of pages	6
Journal	World Journal of Pediatrics
Volume	16
Issue number	6
DOIs	https://doi.org/10.1007/s12519-020-00385-x
Publication status	Published - 2020 Dec 1

Keywords

Anemia
Hepcidin
Inflammation
Kawasaki disease

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1007/s12519-020-00385-x

Fingerprint Dive into the research topics of 'Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification'. Together they form a unique fingerprint.

Cite this

Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification. / Atsumi, Yukari; Sakakibara, Hiroshi; Morikawa, Yoshihiko; Miyata, Koichi; Yamagishi, Hiroyuki; Misawa, Masahiro; Miura, Masaru.

In: World Journal of Pediatrics, Vol. 16, No. 6, 01.12.2020, p. 623-628.

Research output: Contribution to journal › Article › peer-review

@article{602d327479a542e6ad013573bfa5be41,

title = "Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification",

abstract = "Background: Although Kawasaki disease (KD) is known to cause anemia, the relationship between its prognosis and hemoglobin level is less well known. Methods: We herein performed a secondary analysis of data from a previous study (Post-RAISE). Children aged 6 months to 2 years at the time of KD diagnosis were enrolled. Decreased hemoglobin was defined as a decrease > 10% on post-treatment day 2 compared with the level prior to the initial therapy. Results: Of 1253 KD cases, treatment resistance was observed in 209 (17%) and was significantly more frequent in the decreased hemoglobin group (37/167 vs. 172/1086, P = 0.041). Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment (odds ratio 1.53; 95% confidence interval 1.00–2.33; P = 0.048). Conclusions: Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.",

keywords = "Anemia, Hepcidin, Inflammation, Kawasaki disease",

author = "Yukari Atsumi and Hiroshi Sakakibara and Yoshihiko Morikawa and Koichi Miyata and Hiroyuki Yamagishi and Masahiro Misawa and Masaru Miura",

note = "Funding Information: We thank the members of the General Pediatric Department, the Clinical Research Center at Tokyo Metropolitan Children?s Medical Center, and the Post-RAISE group for their support. We also thank Mr. James R Valera for his assistance with editing the final manuscript.",

year = "2020",

month = dec,

day = "1",

doi = "10.1007/s12519-020-00385-x",

language = "English",

volume = "16",

pages = "623--628",

journal = "World Journal of Pediatrics",

issn = "1708-8569",

publisher = "Institute of Pediatrics of Zhejiang University",

number = "6",

}

TY - JOUR

T1 - Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification

AU - Atsumi, Yukari

AU - Sakakibara, Hiroshi

AU - Morikawa, Yoshihiko

AU - Miyata, Koichi

AU - Yamagishi, Hiroyuki

AU - Misawa, Masahiro

AU - Miura, Masaru

N1 - Funding Information: We thank the members of the General Pediatric Department, the Clinical Research Center at Tokyo Metropolitan Children?s Medical Center, and the Post-RAISE group for their support. We also thank Mr. James R Valera for his assistance with editing the final manuscript.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Background: Although Kawasaki disease (KD) is known to cause anemia, the relationship between its prognosis and hemoglobin level is less well known. Methods: We herein performed a secondary analysis of data from a previous study (Post-RAISE). Children aged 6 months to 2 years at the time of KD diagnosis were enrolled. Decreased hemoglobin was defined as a decrease > 10% on post-treatment day 2 compared with the level prior to the initial therapy. Results: Of 1253 KD cases, treatment resistance was observed in 209 (17%) and was significantly more frequent in the decreased hemoglobin group (37/167 vs. 172/1086, P = 0.041). Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment (odds ratio 1.53; 95% confidence interval 1.00–2.33; P = 0.048). Conclusions: Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

AB - Background: Although Kawasaki disease (KD) is known to cause anemia, the relationship between its prognosis and hemoglobin level is less well known. Methods: We herein performed a secondary analysis of data from a previous study (Post-RAISE). Children aged 6 months to 2 years at the time of KD diagnosis were enrolled. Decreased hemoglobin was defined as a decrease > 10% on post-treatment day 2 compared with the level prior to the initial therapy. Results: Of 1253 KD cases, treatment resistance was observed in 209 (17%) and was significantly more frequent in the decreased hemoglobin group (37/167 vs. 172/1086, P = 0.041). Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment (odds ratio 1.53; 95% confidence interval 1.00–2.33; P = 0.048). Conclusions: Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

KW - Anemia

KW - Hepcidin

KW - Inflammation

KW - Kawasaki disease

UR - http://www.scopus.com/inward/record.url?scp=85089894803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85089894803&partnerID=8YFLogxK

U2 - 10.1007/s12519-020-00385-x

DO - 10.1007/s12519-020-00385-x

M3 - Article

C2 - 32852720

AN - SCOPUS:85089894803

VL - 16

SP - 623

EP - 628

JO - World Journal of Pediatrics

JF - World Journal of Pediatrics

SN - 1708-8569

IS - 6

ER -