Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification

Yukari Atsumi, Hiroshi Sakakibara, Yoshihiko Morikawa, Koichi Miyata, Hiroyuki Yamagishi, Masahiro Misawa, Masaru Miura

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although Kawasaki disease (KD) is known to cause anemia, the relationship between its prognosis and hemoglobin level is less well known. Methods: We herein performed a secondary analysis of data from a previous study (Post-RAISE). Children aged 6 months to 2 years at the time of KD diagnosis were enrolled. Decreased hemoglobin was defined as a decrease > 10% on post-treatment day 2 compared with the level prior to the initial therapy. Results: Of 1253 KD cases, treatment resistance was observed in 209 (17%) and was significantly more frequent in the decreased hemoglobin group (37/167 vs. 172/1086, P = 0.041). Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment (odds ratio 1.53; 95% confidence interval 1.00–2.33; P = 0.048). Conclusions: Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

Original languageEnglish
Pages (from-to)623-628
Number of pages6
JournalWorld Journal of Pediatrics
Volume16
Issue number6
DOIs
Publication statusPublished - 2020 Dec 1

Keywords

  • Anemia
  • Hepcidin
  • Inflammation
  • Kawasaki disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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