Decreased Incidence of Acute Cellular Rejection in Low-Muscle-Mass Recipients After Living-donor Liver Transplantation

T. Wakabayashi, Masahiro Shinoda, Hideaki Obara, Minoru Kitago, Hiroshi Yagi, Yuta Abe, Kentaro Matsubara, Y. Yamada, Go Oshima, K. Hirukawa, T. Mizota, T. Hibi, O. Itano, K. Hoshino, Tatsuo Kuroda, Yuukou Kitagawa

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Abstract

Background: Sarcopenia has recently been studied as a potential risk factor for mortality and complications after liver transplantation. We investigated the impact of low muscle mass on postoperative outcomes after living-donor liver transplantation. Methods: Our study population consisted of 100 adult recipients who underwent living-donor liver transplantation in our department between 2005 and 2017. Recipients were divided into a low-muscle-mass group (L group) and a normal-muscle-mass group (N group) based on skeletal muscle index (SMI) values, and postoperative outcomes were compared between the groups. Regarding factors that were significantly different between the groups, multivariate analyses were performed to identify predictive factors. Results: Based on the SMI definition, 47 and 53 of the recipients were categorized as having low muscle mass (L group) and normal muscle mass (N group), respectively. Comparison between the groups revealed a significantly reduced incidence of rejection (10.6% in L group vs 30.2% in N group, P =.017) and increased incidences of bacterial infection (61.7% in L group vs 37.7% in N group, P =.017) in the L group compared with the N group. The survival rate did not differ significantly between the groups. Multivariate analyses indicated that muscle mass was a significant predictive factor for both rejection and bacterial infection. Conclusion: It is important to recognize that muscle mass has an impact not only on bacterial infection but also on rejection in recipients with low muscle mass in the postoperative course of living-donor liver transplantation.

Original languageEnglish
Pages (from-to)3626-3634
Number of pages9
JournalTransplantation Proceedings
Volume50
Issue number10
DOIs
Publication statusPublished - 2018 Dec 1

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Living Donors
Liver Transplantation
Muscles
Incidence
Bacterial Infections
Skeletal Muscle
Multivariate Analysis
Sarcopenia

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

@article{1218147ddfae4078bac7522ad3a49476,
title = "Decreased Incidence of Acute Cellular Rejection in Low-Muscle-Mass Recipients After Living-donor Liver Transplantation",
abstract = "Background: Sarcopenia has recently been studied as a potential risk factor for mortality and complications after liver transplantation. We investigated the impact of low muscle mass on postoperative outcomes after living-donor liver transplantation. Methods: Our study population consisted of 100 adult recipients who underwent living-donor liver transplantation in our department between 2005 and 2017. Recipients were divided into a low-muscle-mass group (L group) and a normal-muscle-mass group (N group) based on skeletal muscle index (SMI) values, and postoperative outcomes were compared between the groups. Regarding factors that were significantly different between the groups, multivariate analyses were performed to identify predictive factors. Results: Based on the SMI definition, 47 and 53 of the recipients were categorized as having low muscle mass (L group) and normal muscle mass (N group), respectively. Comparison between the groups revealed a significantly reduced incidence of rejection (10.6{\%} in L group vs 30.2{\%} in N group, P =.017) and increased incidences of bacterial infection (61.7{\%} in L group vs 37.7{\%} in N group, P =.017) in the L group compared with the N group. The survival rate did not differ significantly between the groups. Multivariate analyses indicated that muscle mass was a significant predictive factor for both rejection and bacterial infection. Conclusion: It is important to recognize that muscle mass has an impact not only on bacterial infection but also on rejection in recipients with low muscle mass in the postoperative course of living-donor liver transplantation.",
author = "T. Wakabayashi and Masahiro Shinoda and Hideaki Obara and Minoru Kitago and Hiroshi Yagi and Yuta Abe and Kentaro Matsubara and Y. Yamada and Go Oshima and K. Hirukawa and T. Mizota and T. Hibi and O. Itano and K. Hoshino and Tatsuo Kuroda and Yuukou Kitagawa",
year = "2018",
month = "12",
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doi = "10.1016/j.transproceed.2018.06.028",
language = "English",
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TY - JOUR

T1 - Decreased Incidence of Acute Cellular Rejection in Low-Muscle-Mass Recipients After Living-donor Liver Transplantation

AU - Wakabayashi, T.

AU - Shinoda, Masahiro

AU - Obara, Hideaki

AU - Kitago, Minoru

AU - Yagi, Hiroshi

AU - Abe, Yuta

AU - Matsubara, Kentaro

AU - Yamada, Y.

AU - Oshima, Go

AU - Hirukawa, K.

AU - Mizota, T.

AU - Hibi, T.

AU - Itano, O.

AU - Hoshino, K.

AU - Kuroda, Tatsuo

AU - Kitagawa, Yuukou

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Sarcopenia has recently been studied as a potential risk factor for mortality and complications after liver transplantation. We investigated the impact of low muscle mass on postoperative outcomes after living-donor liver transplantation. Methods: Our study population consisted of 100 adult recipients who underwent living-donor liver transplantation in our department between 2005 and 2017. Recipients were divided into a low-muscle-mass group (L group) and a normal-muscle-mass group (N group) based on skeletal muscle index (SMI) values, and postoperative outcomes were compared between the groups. Regarding factors that were significantly different between the groups, multivariate analyses were performed to identify predictive factors. Results: Based on the SMI definition, 47 and 53 of the recipients were categorized as having low muscle mass (L group) and normal muscle mass (N group), respectively. Comparison between the groups revealed a significantly reduced incidence of rejection (10.6% in L group vs 30.2% in N group, P =.017) and increased incidences of bacterial infection (61.7% in L group vs 37.7% in N group, P =.017) in the L group compared with the N group. The survival rate did not differ significantly between the groups. Multivariate analyses indicated that muscle mass was a significant predictive factor for both rejection and bacterial infection. Conclusion: It is important to recognize that muscle mass has an impact not only on bacterial infection but also on rejection in recipients with low muscle mass in the postoperative course of living-donor liver transplantation.

AB - Background: Sarcopenia has recently been studied as a potential risk factor for mortality and complications after liver transplantation. We investigated the impact of low muscle mass on postoperative outcomes after living-donor liver transplantation. Methods: Our study population consisted of 100 adult recipients who underwent living-donor liver transplantation in our department between 2005 and 2017. Recipients were divided into a low-muscle-mass group (L group) and a normal-muscle-mass group (N group) based on skeletal muscle index (SMI) values, and postoperative outcomes were compared between the groups. Regarding factors that were significantly different between the groups, multivariate analyses were performed to identify predictive factors. Results: Based on the SMI definition, 47 and 53 of the recipients were categorized as having low muscle mass (L group) and normal muscle mass (N group), respectively. Comparison between the groups revealed a significantly reduced incidence of rejection (10.6% in L group vs 30.2% in N group, P =.017) and increased incidences of bacterial infection (61.7% in L group vs 37.7% in N group, P =.017) in the L group compared with the N group. The survival rate did not differ significantly between the groups. Multivariate analyses indicated that muscle mass was a significant predictive factor for both rejection and bacterial infection. Conclusion: It is important to recognize that muscle mass has an impact not only on bacterial infection but also on rejection in recipients with low muscle mass in the postoperative course of living-donor liver transplantation.

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U2 - 10.1016/j.transproceed.2018.06.028

DO - 10.1016/j.transproceed.2018.06.028

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VL - 50

SP - 3626

EP - 3634

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 10

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