Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Akihito Hishikawa, Kaori Hayashi, Takaya Abe, Mari Kaneko, Hideki Yokoi, Tatsuhiko Azegami, Mari Nakamura, Norifumi Yoshimoto, Takeshi Kanda, Yusuke Sakamaki, Hiroshi Itoh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

Original languageEnglish
Pages (from-to)1318-1332.e4
JournalCell Reports
Volume26
Issue number5
DOIs
Publication statusPublished - 2019 Jan 29

Keywords

  • diabetic nephropathy
  • DNA damage repair
  • DNA methylation
  • podocyte

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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