Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Akihito Hishikawa, Kaori Hayashi, Takaya Abe, Mari Kaneko, Hideki Yokoi, Tatsuhiko Azegami, Mari Nakamura, Norifumi Yoshimoto, Takeshi Kanda, Yusuke Sakamaki, Hiroshi Itoh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

Original languageEnglish
Pages (from-to)1318-1332.e4
JournalCell Reports
Volume26
Issue number5
DOIs
Publication statusPublished - 2019 Jan 29

Fingerprint

Podocytes
DNA Methylation
DNA Repair
Repair
Kidney
DNA
Diabetic Nephropathies
Maintenance
Therapeutics

Keywords

  • diabetic nephropathy
  • DNA damage repair
  • DNA methylation
  • podocyte

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes. / Hishikawa, Akihito; Hayashi, Kaori; Abe, Takaya; Kaneko, Mari; Yokoi, Hideki; Azegami, Tatsuhiko; Nakamura, Mari; Yoshimoto, Norifumi; Kanda, Takeshi; Sakamaki, Yusuke; Itoh, Hiroshi.

In: Cell Reports, Vol. 26, No. 5, 29.01.2019, p. 1318-1332.e4.

Research output: Contribution to journalArticle

Hishikawa, Akihito ; Hayashi, Kaori ; Abe, Takaya ; Kaneko, Mari ; Yokoi, Hideki ; Azegami, Tatsuhiko ; Nakamura, Mari ; Yoshimoto, Norifumi ; Kanda, Takeshi ; Sakamaki, Yusuke ; Itoh, Hiroshi. / Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes. In: Cell Reports. 2019 ; Vol. 26, No. 5. pp. 1318-1332.e4.
@article{dc2b45f3ffcf477d9501317b61a1246b,
title = "Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes",
abstract = "Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.",
keywords = "diabetic nephropathy, DNA damage repair, DNA methylation, podocyte",
author = "Akihito Hishikawa and Kaori Hayashi and Takaya Abe and Mari Kaneko and Hideki Yokoi and Tatsuhiko Azegami and Mari Nakamura and Norifumi Yoshimoto and Takeshi Kanda and Yusuke Sakamaki and Hiroshi Itoh",
year = "2019",
month = "1",
day = "29",
doi = "10.1016/j.celrep.2019.01.005",
language = "English",
volume = "26",
pages = "1318--1332.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

AU - Hishikawa, Akihito

AU - Hayashi, Kaori

AU - Abe, Takaya

AU - Kaneko, Mari

AU - Yokoi, Hideki

AU - Azegami, Tatsuhiko

AU - Nakamura, Mari

AU - Yoshimoto, Norifumi

AU - Kanda, Takeshi

AU - Sakamaki, Yusuke

AU - Itoh, Hiroshi

PY - 2019/1/29

Y1 - 2019/1/29

N2 - Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

AB - Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

KW - diabetic nephropathy

KW - DNA damage repair

KW - DNA methylation

KW - podocyte

UR - http://www.scopus.com/inward/record.url?scp=85060081146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060081146&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.01.005

DO - 10.1016/j.celrep.2019.01.005

M3 - Article

VL - 26

SP - 1318-1332.e4

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 5

ER -