Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.
- diabetic nephropathy
- DNA damage repair
- DNA methylation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)