Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography

Possible relationship between gastroesophageal reflux and metabolic syndrome

Eisuke Iwasaki, Hidekazu Suzuki, Yoshinori Sugino, Tsutomu Iida, Toshihiro Nishizawa, Tatsuhiro Masaoka, Hiroshi Hosoda, Kenji Kangawa, Toshifumi Hibi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Body mass index (BMI) and obesity are reportedly associated with symptoms of gastroesophageal reflux disease (GERD). The present study was designed to investigate the effect of metabolic disorders including obesity on the levels of functional gastroesophageal reflux by videoesophagography. Methods: Twenty-one patients with GERD-associated symptoms were examined by videoesophagography. On their initial visit, all patients completed the Japanese version of the Carlsson-Dent self-administered questionnaire (QUEST). The findings of videoesophagography were evaluated by the X-ray severity scores for gastroesophageal reflux (XRSS), which were defined for the total diagnosis of functional gastroesophageal reflux. Correlation between XRSS scores and physical or metabolic markers was evaluated. Results: The mean XRSS in the QUEST-positive group (4.7 ± 0.6) was significantly higher than that in the QUEST-negative group (3.3 ± 0.5, P < 0.05). XRSS correlated positively with BMI (P < 0.05) and waist circumference (P < 0.05), but negatively with high-density lipoprotein-cholesterol (P < 0.05), serum adiponectin (P < 0.05) and active ghrelin (P < 0.05). In the multivariate analysis, serum adiponectin level, BMI and triglyceride independently affected the XRSS. Conclusion: Videoesophagography is a useful diagnostic modality for the evaluation of patients with GERD symptoms. Functional gastroesophageal reflux is seen in obese patients, especially with decreased levels of adiponectin.

Original languageEnglish
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume23
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2008

Fingerprint

Adiponectin
Gastroesophageal Reflux
X-Rays
Body Mass Index
Obesity
Ghrelin
Waist Circumference
Serum
HDL Cholesterol
Triglycerides
Multivariate Analysis

Keywords

  • Adiponectin
  • Gastroesophageal reflux disease
  • Metabolic syndrome
  • Videoesophagography

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography : Possible relationship between gastroesophageal reflux and metabolic syndrome. / Iwasaki, Eisuke; Suzuki, Hidekazu; Sugino, Yoshinori; Iida, Tsutomu; Nishizawa, Toshihiro; Masaoka, Tatsuhiro; Hosoda, Hiroshi; Kangawa, Kenji; Hibi, Toshifumi.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 23, No. SUPPL. 2, 2008.

Research output: Contribution to journalArticle

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AU - Iida, Tsutomu

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