Deep stromal opacity after corneal cross-linking

Naoko Kato, Kenji Konomi, Megumi Saiki, Kazuno Negishi, Masaru Takeuchi, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: To describe 3 cases with deep corneal stromal opacity that occurred several months after corneal cross-linking. Methods: A 36-year-old man, a 19-year-old man, and a 14-yearold girl underwent corneal cross-linking for their progressive keratoconus. Corneal cross-linking was performed according to the Dresden protocol. The corneal epithelium was ablated using an excimer laser in 2 cases and manually in 1 case. After 30 minutes of riboflavin presoaking, hypotonic riboflavin solution was applied until the corneal stroma swelled, after which the eyes were exposed to ultraviolet irradiation. Slit-lamp microscopy findings, uncorrected visual acuity, best-corrected visual acuity, manifest refraction, intraocular pressure, and corneal endothelial cell counts were evaluated, and corneal topography with Scheimpflug imaging was performed. Results: In all cases, the epithelium healed without delay. All eyes showed mild stromal infiltration a few days after the procedure; however, the inflammation was resolved within 1 week. The corneal stroma revealed no opacity up to 1 month after the procedure. A deep stromal opacity that extended to the inferior paracentral area developed after a few months and remained for 6 months to 1 year. Because the opacity was not on the visual axis, the visual acuity was not involved. Conclusions: Deep stromal opacity developed several months after uneventful corneal cross-linking. Postoperative inflammation may play a crucial role in its pathogenesis.

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalCornea
Volume32
Issue number7
DOIs
Publication statusPublished - 2013 Jul

Fingerprint

Corneal Opacity
Visual Acuity
Corneal Stroma
Riboflavin
Hypotonic Solutions
Corneal Topography
Inflammation
Keratoconus
Excimer Lasers
Corneal Epithelium
Intraocular Pressure
Epithelium
Endothelial Cells
Cell Count

Keywords

  • Complications
  • Corneal cross-linking
  • Keratoconus

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kato, N., Konomi, K., Saiki, M., Negishi, K., Takeuchi, M., Shimazaki, J., & Tsubota, K. (2013). Deep stromal opacity after corneal cross-linking. Cornea, 32(7), 895-898. https://doi.org/10.1097/ICO.0b013e318280c6da

Deep stromal opacity after corneal cross-linking. / Kato, Naoko; Konomi, Kenji; Saiki, Megumi; Negishi, Kazuno; Takeuchi, Masaru; Shimazaki, Jun; Tsubota, Kazuo.

In: Cornea, Vol. 32, No. 7, 07.2013, p. 895-898.

Research output: Contribution to journalArticle

Kato, N, Konomi, K, Saiki, M, Negishi, K, Takeuchi, M, Shimazaki, J & Tsubota, K 2013, 'Deep stromal opacity after corneal cross-linking', Cornea, vol. 32, no. 7, pp. 895-898. https://doi.org/10.1097/ICO.0b013e318280c6da
Kato N, Konomi K, Saiki M, Negishi K, Takeuchi M, Shimazaki J et al. Deep stromal opacity after corneal cross-linking. Cornea. 2013 Jul;32(7):895-898. https://doi.org/10.1097/ICO.0b013e318280c6da
Kato, Naoko ; Konomi, Kenji ; Saiki, Megumi ; Negishi, Kazuno ; Takeuchi, Masaru ; Shimazaki, Jun ; Tsubota, Kazuo. / Deep stromal opacity after corneal cross-linking. In: Cornea. 2013 ; Vol. 32, No. 7. pp. 895-898.
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