Deep stromal opacity after corneal cross-linking

Naoko Kato, Kenji Konomi, Megumi Saiki, Kazuno Negishi, Masaru Takeuchi, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To describe 3 cases with deep corneal stromal opacity that occurred several months after corneal cross-linking. Methods: A 36-year-old man, a 19-year-old man, and a 14-yearold girl underwent corneal cross-linking for their progressive keratoconus. Corneal cross-linking was performed according to the Dresden protocol. The corneal epithelium was ablated using an excimer laser in 2 cases and manually in 1 case. After 30 minutes of riboflavin presoaking, hypotonic riboflavin solution was applied until the corneal stroma swelled, after which the eyes were exposed to ultraviolet irradiation. Slit-lamp microscopy findings, uncorrected visual acuity, best-corrected visual acuity, manifest refraction, intraocular pressure, and corneal endothelial cell counts were evaluated, and corneal topography with Scheimpflug imaging was performed. Results: In all cases, the epithelium healed without delay. All eyes showed mild stromal infiltration a few days after the procedure; however, the inflammation was resolved within 1 week. The corneal stroma revealed no opacity up to 1 month after the procedure. A deep stromal opacity that extended to the inferior paracentral area developed after a few months and remained for 6 months to 1 year. Because the opacity was not on the visual axis, the visual acuity was not involved. Conclusions: Deep stromal opacity developed several months after uneventful corneal cross-linking. Postoperative inflammation may play a crucial role in its pathogenesis.

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalCornea
Volume32
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

Keywords

  • Complications
  • Corneal cross-linking
  • Keratoconus

ASJC Scopus subject areas

  • Ophthalmology

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    Kato, N., Konomi, K., Saiki, M., Negishi, K., Takeuchi, M., Shimazaki, J., & Tsubota, K. (2013). Deep stromal opacity after corneal cross-linking. Cornea, 32(7), 895-898. https://doi.org/10.1097/ICO.0b013e318280c6da