Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome

Kazuo Tsubota, Shinichiro Hirai, Landon S. King, Peter Agre, Naruhiro Ishida

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Dry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of aquaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's syndrome dry eye had the expected apical distribution of AQP5 in lacrimal acinar cells. By contrast, cytoplasmic AQP5 was seen in patients with Sjögren's syndrome. Sodium channel and sodium-potassium ATPase distributions were normal in all groups. These findings show a selective defect in lacrimal gland AQP5 trafficking in Sjögren's syndrome that might contribute to decreased lacrimation and dry eye in these patients.

Original languageEnglish
Pages (from-to)688-689
Number of pages2
JournalLancet
Volume357
Issue number9257
DOIs
Publication statusPublished - 2001 Mar 3

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Aquaporin 5
Lacrimal Apparatus
Mikulicz' Disease
Dry Eye Syndromes
Sodium-Potassium-Exchanging ATPase
Sodium Channels
Acinar Cells
Normal Distribution
Tears
Mouth
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome. / Tsubota, Kazuo; Hirai, Shinichiro; King, Landon S.; Agre, Peter; Ishida, Naruhiro.

In: Lancet, Vol. 357, No. 9257, 03.03.2001, p. 688-689.

Research output: Contribution to journalArticle

Tsubota, Kazuo ; Hirai, Shinichiro ; King, Landon S. ; Agre, Peter ; Ishida, Naruhiro. / Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome. In: Lancet. 2001 ; Vol. 357, No. 9257. pp. 688-689.
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