Defects of Autologous Mixed Lymphocyte Reaction‐Activated Immunoregulatory T Cells in Patients with Systemic Lupus Erythematosus

J. KOIDE, T. TAKEUCHI, O. HOSONO, M. TAKANO, T. ABE

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The present study was undertaken to determine the nature of the immunoregulatory T‐cell defect after autologous mixed lymphocyte reaction (AMLR) activation in patients with systemic lupus erythematosus (SLE). Although AMLR was decreased in patients with SLE compared with normals, there was no difference in major proliferative cells (T4 cells and T4+JRA+ subset) in response to AMLR. Functional activity of AMLR‐stimulated T4 subsets in patients with SLE and normals was examined in helper and suppressor/inducer assay, using pokeweed mitogen (PWM)‐driven IgG synthesis. The T4+JRA (helper) subset from SLE patients showed no greater activity than normals. However the T4+JRA+ (suppressor/inducer) subset from SLE patients showed decreased suppression induction compared with normals. This defect in the suppressor/inducer function was demonstrated even in patients with inactive SLR or in remission.

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalScandinavian Journal of Immunology
Volume26
Issue number4
DOIs
Publication statusPublished - 1987 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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