Defining the role of Lgr5+ stem cells in colorectal cancer: From basic research to clinical applications

Masayuki Fujii; Toshiro Sato

doi:10.1186/s13073-017-0460-y

Defining the role of Lgr5⁺ stem cells in colorectal cancer: From basic research to clinical applications

Masayuki Fujii, Toshiro Sato

The Sakaguchi Laboratory of Developmental Biology Department of Organoid Medicine

Research output: Contribution to journal › Comment/debate › peer-review

6 Citations (Scopus)

Abstract

Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5⁺ intestinal stem cells, providing insights into their roles in homeostasis and cancer.

Original language	English
Article number	66
Journal	Genome Medicine
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s13073-017-0460-y
Publication status	Published - 2017 Jul 18

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s13073-017-0460-y

Cite this

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abstract = "Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5+ intestinal stem cells, providing insights into their roles in homeostasis and cancer.",

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