Defining the role of Lgr5+ stem cells in colorectal cancer: From basic research to clinical applications

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5+ intestinal stem cells, providing insights into their roles in homeostasis and cancer.

Original languageEnglish
Article number66
JournalGenome Medicine
Volume9
Issue number1
DOIs
Publication statusPublished - 2017 Jul 18

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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