Defining the role of Lgr5+ stem cells in colorectal cancer: From basic research to clinical applications

Masayuki Fujii, Toshiro Sato

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5+ intestinal stem cells, providing insights into their roles in homeostasis and cancer.

Original languageEnglish
Article number66
JournalGenome Medicine
Volume9
Issue number1
DOIs
Publication statusPublished - 2017 Jul 18

Fingerprint

Colorectal Neoplasms
Stem Cells
Research
Organoids
Intestinal Mucosa
Homeostasis
Technology
Neoplasms

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Defining the role of Lgr5+ stem cells in colorectal cancer : From basic research to clinical applications. / Fujii, Masayuki; Sato, Toshiro.

In: Genome Medicine, Vol. 9, No. 1, 66, 18.07.2017.

Research output: Contribution to journalComment/debate

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