TY - JOUR
T1 - Degradation of thermoresponsive laponite/PEG-b-PLGA nanocomposite hydrogels controlled by blending PEG-b-PLGA diblock copolymers with different PLGA molecular weights
AU - Maeda, Tomoki
AU - Kitagawa, Midori
AU - Hotta, Atsushi
N1 - Funding Information:
This work was supported in part by the Leading Initiatives for Excellent Young Researchers (LEADER) (T.M.), by a Grant-in-Aid for Scientific Research (A) (no. 19H00831 to A.H. and T.M.), and by a Grant-in-Aid for Scientific Research (B) (no. 20H02023 to T.M. and A.H.) from the Japan Society for the Promotion of Science ( JSPS : “KAKENHI”). The SANS measurements were performed at BL-20 (iMATERIA) in the Materials and Life Science Experimental Facility (MLF), Japan Proton Accelerator Research Complex (J-PARC), Tokai, Japan (Proposal No. 2019PM3003 and 2020PM3004 ).
Funding Information:
This work was supported in part by the Leading Initiatives for Excellent Young Researchers (LEADER) (T.M.), by a Grant-in-Aid for Scientific Research (A) (no. 19H00831 to A.H. and T.M.), and by a Grant-in-Aid for Scientific Research (B) (no. 20H02023 to T.M. and A.H.) from the Japan Society for the Promotion of Science (JSPS: “KAKENHI”). The SANS measurements were performed at BL-20 (iMATERIA) in the Materials and Life Science Experimental Facility (MLF), Japan Proton Accelerator Research Complex (J-PARC), Tokai, Japan (Proposal No. 2019PM3003 and 2020PM3004).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/5
Y1 - 2021/5
N2 - The thermoresponsive gelation behavior and the degradation behavior of the nanocomposites consisting of poly(ethylene glycol)-b-poly(lactic acid-co-glycolic acid) (PEG-b-PLGA) diblock copolymers and clay nanoparticles (laponite) (laponite/PEG-b-PLGA nanocomposites) were studied by changing the blend ratio of the PEG-b-PLGA diblock copolymers using different PLGA molecular weights of 800 g/mol and 1600 g/mol: PEG-b-PLGA (1000-800, Diblock0.8k) and PEG-b-PLGA (1000-1600, Diblock1.6k). It was found that each gelation temperature was in the temperature range between 25°C and 37°C, when the PEG-b-PLGA concentration and the laponite concentration were kept at 3–4 wt% and 1 wt%, respectively. The degradation rate at 37°C was found to be effectively regulated by the Diblock1.6k/Diblock0.8k blend ratio (DR). In detail, after 15 days of the degradation experiments, the weight loss was decreased by ∼14% when DR changed from DR=0/100 to DR=100/0. It was, therefore, confirmed that DR was the key parameter to control the degradation behavior of the laponite/blended PEG-b-PLGA nanocomposites.
AB - The thermoresponsive gelation behavior and the degradation behavior of the nanocomposites consisting of poly(ethylene glycol)-b-poly(lactic acid-co-glycolic acid) (PEG-b-PLGA) diblock copolymers and clay nanoparticles (laponite) (laponite/PEG-b-PLGA nanocomposites) were studied by changing the blend ratio of the PEG-b-PLGA diblock copolymers using different PLGA molecular weights of 800 g/mol and 1600 g/mol: PEG-b-PLGA (1000-800, Diblock0.8k) and PEG-b-PLGA (1000-1600, Diblock1.6k). It was found that each gelation temperature was in the temperature range between 25°C and 37°C, when the PEG-b-PLGA concentration and the laponite concentration were kept at 3–4 wt% and 1 wt%, respectively. The degradation rate at 37°C was found to be effectively regulated by the Diblock1.6k/Diblock0.8k blend ratio (DR). In detail, after 15 days of the degradation experiments, the weight loss was decreased by ∼14% when DR changed from DR=0/100 to DR=100/0. It was, therefore, confirmed that DR was the key parameter to control the degradation behavior of the laponite/blended PEG-b-PLGA nanocomposites.
KW - Degradation
KW - Laponite
KW - Nanocomposite
KW - Poly(ethylene glycol)
KW - Poly(lactic acid-co-glycolic acid)
KW - Thermoresponsive hydrogel
UR - http://www.scopus.com/inward/record.url?scp=85102254682&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102254682&partnerID=8YFLogxK
U2 - 10.1016/j.polymdegradstab.2021.109535
DO - 10.1016/j.polymdegradstab.2021.109535
M3 - Article
AN - SCOPUS:85102254682
SN - 0141-3910
VL - 187
JO - Polymer Degradation and Stability
JF - Polymer Degradation and Stability
M1 - 109535
ER -