Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

Yasunori Okada, Hiroshi Konomi, Toshikazu Yada, Koji Kimata, Hideaki Nagase

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalFEBS Letters
Volume244
Issue number2
DOIs
Publication statusPublished - 1989 Feb 27

Keywords

  • Degradation
  • Extracellular matrix
  • Proteinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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