Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

Yasunori Okada; Hiroshi Konomi; Toshikazu Yada; Koji Kimata; Hideaki Nagase

doi:10.1016/0014-5793(89)80586-1

Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

Yasunori Okada, Hiroshi Konomi, Toshikazu Yada, Koji Kimata, Hideaki Nagase

Department of Pathology

Research output: Contribution to journal › Article

76 Citations (Scopus)

Abstract

The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.

Original language	English
Pages (from-to)	473-476
Number of pages	4
Journal	FEBS Letters
Volume	244
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)80586-1
Publication status	Published - 1989 Feb 27

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Keywords

Degradation
Extracellular matrix
Proteinase

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Okada, Y., Konomi, H., Yada, T., Kimata, K., & Nagase, H. (1989). Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells. FEBS Letters, 244(2), 473-476. https://doi.org/10.1016/0014-5793(89)80586-1

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10.1016/0014-5793(89)80586-1