Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

Yasunori Okada; Hiroshi Konomi; Toshikazu Yada; Koji Kimata; Hideaki Nagase

doi:10.1016/0014-5793(89)80586-1

Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

Yasunori Okada, Hiroshi Konomi, Toshikazu Yada, Koji Kimata, Hideaki Nagase

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.

Original language	English
Pages (from-to)	473-476
Number of pages	4
Journal	FEBS Letters
Volume	244
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)80586-1
Publication status	Published - 1989 Feb 27
Externally published	Yes

Keywords

Degradation
Extracellular matrix
Proteinase

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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abstract = "The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.",

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AU - Okada, Yasunori

AU - Konomi, Hiroshi

AU - Yada, Toshikazu

AU - Kimata, Koji

AU - Nagase, Hideaki

PY - 1989/2/27

Y1 - 1989/2/27

N2 - The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.

AB - The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.

KW - Degradation

KW - Extracellular matrix

KW - Proteinase

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