Delayed bleeding after endoscopic submucosal dissection for non-ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure

Analysis of risk factors

Shu Hoteya, Mitsuru Kaise, Toshiro Iizuka, Osamu Ogawa, Toshifumi Mitani, Akira Matsui, Daisuke Kikuchi, Tsukasa Furuhata, Satoshi Yamashita, Akihiro Yamada, Ryusuke Kimura, Kousuke Nomura, Yasutaka Kuribayashi, Yoshifumi Miyata, Naohisa Yahagi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background and Aim Duodenal endoscopic submucosal dissection (ESD) is technically challenging because of anatomical specificities and, to date, has not been validated concerning the high rate of complications such as perforation and delayed bleeding. In the present study, the risk factors for delayed bleeding after duodenal ESD are presented with the goal of establishing preventive measures. Methods We analyzed 63 patients with non-ampullary superficial duodenal neoplasias treated by ESD from April 2005 to March 2014. To analyze the risk factors of delayed bleeding after duodenal ESD, we divided the patients into a delayed bleeding group and a non-bleeding group. To verify the risk factors of delayed bleeding after duodenal ESD, we analyzed various patient-, lesion-, and treatment-related factors. Results Delayed bleeding was experienced in 11 patients (17.5%) Univariate analysis of patient-related risk factors of delayed bleeding indicated no significant risk factor. Univariate analysis of lesion-related and treatment-related risk factors indicated only endoscopic closure as a significant risk factor. Multivariate analysis also identified endoscopic closure (not done > done: P = 0.049) as an independent factor significantly associated with delayed bleeding after duodenal ESD. Hypertension (present > absent: P = 0.055) showed a non-significant tendency of association by multivariate analysis. Conclusions This retrospective evaluation found that endoscopic closure was associated with a reduced risk of delayed bleeding after duodenal ESD. Delayed bleeding after duodenal ESD might be prevented by prophylactic endoscopic closure.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalDigestive Endoscopy
Volume27
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

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Hemorrhage
Neoplasms
Multivariate Analysis
Endoscopic Mucosal Resection
Hypertension
Therapeutics

Keywords

  • complication
  • delayed bleeding
  • endoscopic closure
  • endoscopic submucosal dissection (ESD)
  • superficial duodenal neoplasia

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Delayed bleeding after endoscopic submucosal dissection for non-ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure : Analysis of risk factors. / Hoteya, Shu; Kaise, Mitsuru; Iizuka, Toshiro; Ogawa, Osamu; Mitani, Toshifumi; Matsui, Akira; Kikuchi, Daisuke; Furuhata, Tsukasa; Yamashita, Satoshi; Yamada, Akihiro; Kimura, Ryusuke; Nomura, Kousuke; Kuribayashi, Yasutaka; Miyata, Yoshifumi; Yahagi, Naohisa.

In: Digestive Endoscopy, Vol. 27, No. 3, 01.03.2015, p. 323-330.

Research output: Contribution to journalArticle

Hoteya, S, Kaise, M, Iizuka, T, Ogawa, O, Mitani, T, Matsui, A, Kikuchi, D, Furuhata, T, Yamashita, S, Yamada, A, Kimura, R, Nomura, K, Kuribayashi, Y, Miyata, Y & Yahagi, N 2015, 'Delayed bleeding after endoscopic submucosal dissection for non-ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure: Analysis of risk factors', Digestive Endoscopy, vol. 27, no. 3, pp. 323-330. https://doi.org/10.1111/den.12377
Hoteya, Shu ; Kaise, Mitsuru ; Iizuka, Toshiro ; Ogawa, Osamu ; Mitani, Toshifumi ; Matsui, Akira ; Kikuchi, Daisuke ; Furuhata, Tsukasa ; Yamashita, Satoshi ; Yamada, Akihiro ; Kimura, Ryusuke ; Nomura, Kousuke ; Kuribayashi, Yasutaka ; Miyata, Yoshifumi ; Yahagi, Naohisa. / Delayed bleeding after endoscopic submucosal dissection for non-ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure : Analysis of risk factors. In: Digestive Endoscopy. 2015 ; Vol. 27, No. 3. pp. 323-330.
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abstract = "Background and Aim Duodenal endoscopic submucosal dissection (ESD) is technically challenging because of anatomical specificities and, to date, has not been validated concerning the high rate of complications such as perforation and delayed bleeding. In the present study, the risk factors for delayed bleeding after duodenal ESD are presented with the goal of establishing preventive measures. Methods We analyzed 63 patients with non-ampullary superficial duodenal neoplasias treated by ESD from April 2005 to March 2014. To analyze the risk factors of delayed bleeding after duodenal ESD, we divided the patients into a delayed bleeding group and a non-bleeding group. To verify the risk factors of delayed bleeding after duodenal ESD, we analyzed various patient-, lesion-, and treatment-related factors. Results Delayed bleeding was experienced in 11 patients (17.5{\%}) Univariate analysis of patient-related risk factors of delayed bleeding indicated no significant risk factor. Univariate analysis of lesion-related and treatment-related risk factors indicated only endoscopic closure as a significant risk factor. Multivariate analysis also identified endoscopic closure (not done > done: P = 0.049) as an independent factor significantly associated with delayed bleeding after duodenal ESD. Hypertension (present > absent: P = 0.055) showed a non-significant tendency of association by multivariate analysis. Conclusions This retrospective evaluation found that endoscopic closure was associated with a reduced risk of delayed bleeding after duodenal ESD. Delayed bleeding after duodenal ESD might be prevented by prophylactic endoscopic closure.",
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AU - Hoteya, Shu

AU - Kaise, Mitsuru

AU - Iizuka, Toshiro

AU - Ogawa, Osamu

AU - Mitani, Toshifumi

AU - Matsui, Akira

AU - Kikuchi, Daisuke

AU - Furuhata, Tsukasa

AU - Yamashita, Satoshi

AU - Yamada, Akihiro

AU - Kimura, Ryusuke

AU - Nomura, Kousuke

AU - Kuribayashi, Yasutaka

AU - Miyata, Yoshifumi

AU - Yahagi, Naohisa

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N2 - Background and Aim Duodenal endoscopic submucosal dissection (ESD) is technically challenging because of anatomical specificities and, to date, has not been validated concerning the high rate of complications such as perforation and delayed bleeding. In the present study, the risk factors for delayed bleeding after duodenal ESD are presented with the goal of establishing preventive measures. Methods We analyzed 63 patients with non-ampullary superficial duodenal neoplasias treated by ESD from April 2005 to March 2014. To analyze the risk factors of delayed bleeding after duodenal ESD, we divided the patients into a delayed bleeding group and a non-bleeding group. To verify the risk factors of delayed bleeding after duodenal ESD, we analyzed various patient-, lesion-, and treatment-related factors. Results Delayed bleeding was experienced in 11 patients (17.5%) Univariate analysis of patient-related risk factors of delayed bleeding indicated no significant risk factor. Univariate analysis of lesion-related and treatment-related risk factors indicated only endoscopic closure as a significant risk factor. Multivariate analysis also identified endoscopic closure (not done > done: P = 0.049) as an independent factor significantly associated with delayed bleeding after duodenal ESD. Hypertension (present > absent: P = 0.055) showed a non-significant tendency of association by multivariate analysis. Conclusions This retrospective evaluation found that endoscopic closure was associated with a reduced risk of delayed bleeding after duodenal ESD. Delayed bleeding after duodenal ESD might be prevented by prophylactic endoscopic closure.

AB - Background and Aim Duodenal endoscopic submucosal dissection (ESD) is technically challenging because of anatomical specificities and, to date, has not been validated concerning the high rate of complications such as perforation and delayed bleeding. In the present study, the risk factors for delayed bleeding after duodenal ESD are presented with the goal of establishing preventive measures. Methods We analyzed 63 patients with non-ampullary superficial duodenal neoplasias treated by ESD from April 2005 to March 2014. To analyze the risk factors of delayed bleeding after duodenal ESD, we divided the patients into a delayed bleeding group and a non-bleeding group. To verify the risk factors of delayed bleeding after duodenal ESD, we analyzed various patient-, lesion-, and treatment-related factors. Results Delayed bleeding was experienced in 11 patients (17.5%) Univariate analysis of patient-related risk factors of delayed bleeding indicated no significant risk factor. Univariate analysis of lesion-related and treatment-related risk factors indicated only endoscopic closure as a significant risk factor. Multivariate analysis also identified endoscopic closure (not done > done: P = 0.049) as an independent factor significantly associated with delayed bleeding after duodenal ESD. Hypertension (present > absent: P = 0.055) showed a non-significant tendency of association by multivariate analysis. Conclusions This retrospective evaluation found that endoscopic closure was associated with a reduced risk of delayed bleeding after duodenal ESD. Delayed bleeding after duodenal ESD might be prevented by prophylactic endoscopic closure.

KW - complication

KW - delayed bleeding

KW - endoscopic closure

KW - endoscopic submucosal dissection (ESD)

KW - superficial duodenal neoplasia

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DO - 10.1111/den.12377

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