Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy

Toshiki Takenouchi, Elayna O. Rubens, Vivien L. Yap, Gail Ross, Murray Engel, Jeffrey M. Perlman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: To determine whether hypothermia modulates acquisition of sleep-wake cycling in term neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE) and the relationship to outcome. Study design: Twenty-nine term infants with moderate to severe HIE treated with selective head cooling were evaluated. All were monitored with amplitude-integrated electroencephalography during and video electroencephalography immediately after hypothermia for ≥72 hours. Electroencephalograpic data were analyzed for background and sleep-wake cycling. Abnormal outcome included death or severe global neurodevelopmental disability ≥18 months. Results: Acquisition of sleep-wake cycling was noted in nine infants by 72 hours, in 13 by 96 hours, 19 by 120 hours, and 22 by 144 hours. Presence of sleep-wake cycling was associated with normal outcome, that is, 14 of 22 (64%), versus abnormal outcome, that is, none of seven without sleep-wake cycling (P =.006). The presence of sleep-wake cycling by 120 hours had a positive predictive value of 68% and negative predictive value of 90%. Magnetic resonance imaging abnormalities were related to onset of sleep-wake cycling. Conclusions: Although onset of sleep-wake cycling is markedly delayed in term neonates with moderate to severe HIE treated with hypothermia, approximately 65% with acquisition of cycling have a normal outcome. Sleep-wake cycling is an important additional tool for assessing recovery in term infants with moderate to severe HIE treated with hypothermia.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalJournal of Pediatrics
Volume159
Issue number2
DOIs
Publication statusPublished - 2011 Aug
Externally publishedYes

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Brain Diseases
Sleep
Newborn Infant
Brain Hypoxia-Ischemia
Hypothermia
Electroencephalography
Head
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy. / Takenouchi, Toshiki; Rubens, Elayna O.; Yap, Vivien L.; Ross, Gail; Engel, Murray; Perlman, Jeffrey M.

In: Journal of Pediatrics, Vol. 159, No. 2, 08.2011, p. 232-237.

Research output: Contribution to journalArticle

Takenouchi, Toshiki ; Rubens, Elayna O. ; Yap, Vivien L. ; Ross, Gail ; Engel, Murray ; Perlman, Jeffrey M. / Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy. In: Journal of Pediatrics. 2011 ; Vol. 159, No. 2. pp. 232-237.
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