Delayed radiation necrosis with extensive brain edema after gamma knife radiosurgery for multiple cerebral cavernous malformations: Case report

Nobuo Takenaka, Tomoyuki Imanishi, Hikaru Sasaki, Kenji Shimazaki, Hitoshi Sugiura, Yasuhisa Kitagawa, Sari Sekiyama, Masaaki Yamamoto, Takahito Kazuno

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A 39-year-old man presented with multiple intracranial cavernous malformations manifesting as intractable seizures persisting for more than 20 years. He underwent gamma knife radiosurgery (GKRS) for right frontal and left temporal cavernous malformations. He began to suffer from progressive left hemiparesis and inattention 2 years 5 months after the GKRS. Magnetic resonance imaging showed abnormal ring enhancement and extensive brain edema around the right frontal lesion. Conservative therapies such as external decompression, low-dose barbiturates, and mild hypothermia had no effect on his clinical status. Stereotactic biopsy of the ring-enhanced area demonstrated gliosis. Signs of cerebral herniation appeared, so we performed partial resection of the right frontal lobe. His symptoms recovered immediately. Subsequent hyperbaric oxygen (HBO) therapy significantly improved the extensive brain edema. Delayed radiation necrosis associated with potentially fatal brain edema may occur after GKRS for cavernous malformations. Internal decompression and subsequent HBO therapy were very effective for the treatment of these lesions.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalNeurologia Medico-Chirurgica
Volume43
Issue number8
DOIs
Publication statusPublished - 2003 Aug 1
Externally publishedYes

Fingerprint

Central Nervous System Cavernous Hemangioma
Radiosurgery
Brain Edema
Hyperbaric Oxygenation
Necrosis
Radiation
Decompression
Barbiturates
Gliosis
Frontal Lobe
Paresis
Hypothermia
Seizures
Magnetic Resonance Imaging
Biopsy
Therapeutics

Keywords

  • Cavernous malformation
  • Decompression
  • Gamma knife
  • Hyperbaric oxygen therapy
  • Radiation necrosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Delayed radiation necrosis with extensive brain edema after gamma knife radiosurgery for multiple cerebral cavernous malformations : Case report. / Takenaka, Nobuo; Imanishi, Tomoyuki; Sasaki, Hikaru; Shimazaki, Kenji; Sugiura, Hitoshi; Kitagawa, Yasuhisa; Sekiyama, Sari; Yamamoto, Masaaki; Kazuno, Takahito.

In: Neurologia Medico-Chirurgica, Vol. 43, No. 8, 01.08.2003, p. 391-395.

Research output: Contribution to journalArticle

Takenaka, Nobuo ; Imanishi, Tomoyuki ; Sasaki, Hikaru ; Shimazaki, Kenji ; Sugiura, Hitoshi ; Kitagawa, Yasuhisa ; Sekiyama, Sari ; Yamamoto, Masaaki ; Kazuno, Takahito. / Delayed radiation necrosis with extensive brain edema after gamma knife radiosurgery for multiple cerebral cavernous malformations : Case report. In: Neurologia Medico-Chirurgica. 2003 ; Vol. 43, No. 8. pp. 391-395.
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