Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency

Fabrice G. Petit, Soazik P. Jamin, Isao Kurihara, Richard R. Behringer, Francesco J. DeMayo, Ming Jer Tsai, Sophia Y. Tsai

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

COUP-TFII (NR2F2), chicken ovalbumin upstream promoter-transcription factor II, is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily. The Coup-tfll-null mutant mice die during the early embryonic development because of angiogenesis and heart defects. To analyze the physiological function of COUP-TFII during organogenesis, we used the cre/loxP system to conditionally inactivate COUP-TFII in the ovary and uterus. Homozygous adult female mutants with specific inactivation of the Coup-tfll gene in uterine stromal and smooth muscle cells have severely impaired placental formation, leading to miscarriage at days 10-12 of pregnancy. Deletion of the Coup-tfll gene resulted in an increase in trophoblast giant cell differentiation, a reduction of the spongiotrophoblast layer, and an absence of labyrinth formation causing an improper vascularization of the placenta. This study describes an important maternal role of COUP-TFII in regulating the placentation. The endometrial COUP-TFII might modulate the signaling between the uterus and the extraembryonic tissue for the proper formation of the placenta.

Original languageEnglish
Pages (from-to)6293-6298
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number15
DOIs
Publication statusPublished - 2007 Apr 10
Externally publishedYes

Fingerprint

Orphan Nuclear Receptors
Placenta
COUP Transcription Factor II
Uterus
Thyroid Hormone Receptors
Placentation
Organogenesis
Myometrium
Trophoblasts
Spontaneous Abortion
Inner Ear
Giant Cells
Genes
Smooth Muscle Myocytes
Embryonic Development
Cell Differentiation
Ovary
Steroids
Mothers
Pregnancy

Keywords

  • Placenta
  • Reproduction
  • Trophoblast giant cell

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency. / Petit, Fabrice G.; Jamin, Soazik P.; Kurihara, Isao; Behringer, Richard R.; DeMayo, Francesco J.; Tsai, Ming Jer; Tsai, Sophia Y.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 15, 10.04.2007, p. 6293-6298.

Research output: Contribution to journalArticle

Petit, Fabrice G. ; Jamin, Soazik P. ; Kurihara, Isao ; Behringer, Richard R. ; DeMayo, Francesco J. ; Tsai, Ming Jer ; Tsai, Sophia Y. / Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 15. pp. 6293-6298.
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