Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

Makoto Ogura, Shunichi Sato, Mitsuhiro Terakawa, Hitoshi Wakisaka, Maki Uenoyama, Tomosumi Ikeda, Hiroshi Ashida, Minoru Obara

Research output: Contribution to journalLetter

12 Citations (Scopus)

Abstract

We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.

Original languageEnglish
Pages (from-to)L977-L979
JournalJapanese Journal of Applied Physics, Part 2: Letters
Volume42
Issue number8 A
Publication statusPublished - 2003 Aug 1

    Fingerprint

Keywords

  • Drug delivery
  • Laser-induced stress wave
  • Photodynamic therapy
  • Photofrin II
  • Photosensitizer
  • Q-switched Nd:YAG laser
  • Shock wave

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy (miscellaneous)
  • Physics and Astronomy(all)

Cite this

Ogura, M., Sato, S., Terakawa, M., Wakisaka, H., Uenoyama, M., Ikeda, T., Ashida, H., & Obara, M. (2003). Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse. Japanese Journal of Applied Physics, Part 2: Letters, 42(8 A), L977-L979.