TY - JOUR
T1 - Delphinidin 3,5-O-diglucoside, a constituent of the maqui berry (Aristotelia chilensis) anthocyanin, restores tear secretion in a rat dry eye model
AU - Nakamura, Shigeru
AU - Tanaka, Junji
AU - Imada, Toshihiro
AU - Shimoda, Hiroshi
AU - Tsubota, Kazuo
N1 - Funding Information:
This research was supported by a grant from Oryza Oil & Fat Chemical Co., Ltd . The authors thank Takashi Kadekaru, Sachiko Shimoda, and Kohei Yoshimoto for their assistance.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Dry eye disease is a disorder in tear film physiology, which leads to various abnormal states of ocular surface cells. In the present study, we evaluated the potential usefulness of orally applied maqui berry (. Aristotelia chilensis) extract and the constituent anthocyanin as a preventative intervention in dry eye. Tear secretion capacity was evaluated following the oral administration of maqui berry extract to a rat blink-suppressed dry eye model. This suppressive effect of maqui berry extract and its constituent anthocyanins on reactive oxygen species formation from lacrimal gland was elevated by 2', 7'-dichlorofluorescin diacetate. Maqui berry extract and delphinidin 3,5-O-diglucoside, an anthocyanin specifically contained in the maqui berry, suppressed reactive oxygen species formation from lacrimal gland tissue and preserved tear secretion. The result of the present study demonstrates that maqui berry extract can be used as a preventative intervention for dry eye by managing tear secretion capacity in the lacrimal gland.
AB - Dry eye disease is a disorder in tear film physiology, which leads to various abnormal states of ocular surface cells. In the present study, we evaluated the potential usefulness of orally applied maqui berry (. Aristotelia chilensis) extract and the constituent anthocyanin as a preventative intervention in dry eye. Tear secretion capacity was evaluated following the oral administration of maqui berry extract to a rat blink-suppressed dry eye model. This suppressive effect of maqui berry extract and its constituent anthocyanins on reactive oxygen species formation from lacrimal gland was elevated by 2', 7'-dichlorofluorescin diacetate. Maqui berry extract and delphinidin 3,5-O-diglucoside, an anthocyanin specifically contained in the maqui berry, suppressed reactive oxygen species formation from lacrimal gland tissue and preserved tear secretion. The result of the present study demonstrates that maqui berry extract can be used as a preventative intervention for dry eye by managing tear secretion capacity in the lacrimal gland.
KW - Anthocyanin
KW - Dry eye
KW - Ophthalmology
KW - Reactive oxygen species
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U2 - 10.1016/j.jff.2014.06.027
DO - 10.1016/j.jff.2014.06.027
M3 - Article
AN - SCOPUS:84920008568
VL - 10
SP - 346
EP - 354
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
ER -