Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide

Toshinori Abe, Tatsuya Aikawa, Yoshihiro Akahane, Masahiro Arai, Yasuhiro Asahina, Yoshinari Atarashi, Kazuaki Chayama, Hideharu Harada, Naoaki Hashimoto, Akiko Hori, Takafumi Ichida, Hiroki Ikeda, Akihisa Ishikawa, Takayoshi Ito, Jong Hon Kang, Yoshiyasu Karino, Hideaki Kato, Masaru Kato, Mari Kawakami, Naoto KitajimaTsuneo Kitamura, Naohiko Masaki, Keiji Matsubayashi, Hiroyuki Matsuda, Atsushi Matsui, Kojiro Michitaka, Hiroshi Mihara, Katsuhiko Miyaji, Hiroshi Miyakawa, Hitoshi Mizuo, Satoshi Mochida, Mitsuhiko Moriyama, Shuhei Nishiguchi, Katsuo Okada, Hidetsugu Saito, Hiroshi Sakugawa, Minoru Shibata, Kazuyuki Suzuki, Kazuaki Takahashi, Gotaro Yamada, Kazuhide Yamamoto, Taro Yamanaka, Hiroaki Yamato, Koji Yano, Shunji Mishiro

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

To know the reality of hepatitis E virus (HEV) infections in Japan, quite obscure until a few years ago, we have collected a total of 254 human cases of HEV infection, and analyzed for demographic, epidemiological, and virological characteristics. As a result, we now know [i] HEV has penetrated nationwide from Hokkaido to Okinawa; [ii] hepatitis E is a disease of middle-aged people (approx. 50 years old in average) with a predominance of male over female (approx. 3.5 vs 1); [iii] HEV strains of genotype 3 and 4 are autochthonous in Japan, but the latter is present almost exclusively in Hokkaido; [iv] the older the age the severer the disease; [v] HEV genotype 4 is associated with more obvious and severer clinical manifestations than genotype 3; [vi] no seasonality in its incidence; and [vii] transmission routes remain obscure in most cases (approx. 60%), whereas about 30%, 8%, and 2% are ascribable to zoonotic food-borne transmission, imported infection, and via blood transfusion, respectively.

Original languageEnglish
Pages (from-to)384-391
Number of pages8
JournalActa Hepatologica Japonica
Volume47
Issue number8
DOIs
Publication statusPublished - 2006 Dec 1

    Fingerprint

ASJC Scopus subject areas

  • Hepatology

Cite this

Abe, T., Aikawa, T., Akahane, Y., Arai, M., Asahina, Y., Atarashi, Y., Chayama, K., Harada, H., Hashimoto, N., Hori, A., Ichida, T., Ikeda, H., Ishikawa, A., Ito, T., Kang, J. H., Karino, Y., Kato, H., Kato, M., Kawakami, M., ... Mishiro, S. (2006). Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide. Acta Hepatologica Japonica, 47(8), 384-391. https://doi.org/10.2957/kanzo.47.384