Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide

Toshinori Abe; Tatsuya Aikawa; Yoshihiro Akahane; Masahiro Arai; Yasuhiro Asahina; Yoshinari Atarashi; Kazuaki Chayama; Hideharu Harada; Naoaki Hashimoto; Akiko Hori; Takafumi Ichida; Hiroki Ikeda; Akihisa Ishikawa; Takayoshi Ito; Jong Hon Kang; Yoshiyasu Karino; Hideaki Kato; Masaru Kato; Mari Kawakami; Naoto Kitajima; Tsuneo Kitamura; Naohiko Masaki; Keiji Matsubayashi; Hiroyuki Matsuda; Atsushi Matsui; Kojiro Michitaka; Hiroshi Mihara; Katsuhiko Miyaji; Hiroshi Miyakawa; Hitoshi Mizuo; Satoshi Mochida; Mitsuhiko Moriyama; Shuhei Nishiguchi; Katsuo Okada; Hidetsugu Saito; Hiroshi Sakugawa; Minoru Shibata; Kazuyuki Suzuki; Kazuaki Takahashi; Gotaro Yamada; Kazuhide Yamamoto; Taro Yamanaka; Hiroaki Yamato; Koji Yano; Shunji Mishiro

doi:10.2957/kanzo.47.384

Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide

Toshinori Abe, Tatsuya Aikawa, Yoshihiro Akahane, Masahiro Arai, Yasuhiro Asahina, Yoshinari Atarashi, Kazuaki Chayama, Hideharu Harada, Naoaki Hashimoto, Akiko Hori, Takafumi Ichida, Hiroki Ikeda, Akihisa Ishikawa, Takayoshi Ito, Jong Hon Kang, Yoshiyasu Karino, Hideaki Kato, Masaru Kato, Mari Kawakami, Naoto KitajimaTsuneo Kitamura, Naohiko Masaki, Keiji Matsubayashi, Hiroyuki Matsuda, Atsushi Matsui, Kojiro Michitaka, Hiroshi Mihara, Katsuhiko Miyaji, Hiroshi Miyakawa, Hitoshi Mizuo, Satoshi Mochida, Mitsuhiko Moriyama, Shuhei Nishiguchi, Katsuo Okada, Hidetsugu Saito, Hiroshi Sakugawa, Minoru Shibata, Kazuyuki Suzuki, Kazuaki Takahashi, Gotaro Yamada, Kazuhide Yamamoto, Taro Yamanaka, Hiroaki Yamato, Koji Yano, Shunji Mishiro

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

To know the reality of hepatitis E virus (HEV) infections in Japan, quite obscure until a few years ago, we have collected a total of 254 human cases of HEV infection, and analyzed for demographic, epidemiological, and virological characteristics. As a result, we now know [i] HEV has penetrated nationwide from Hokkaido to Okinawa; [ii] hepatitis E is a disease of middle-aged people (approx. 50 years old in average) with a predominance of male over female (approx. 3.5 vs 1); [iii] HEV strains of genotype 3 and 4 are autochthonous in Japan, but the latter is present almost exclusively in Hokkaido; [iv] the older the age the severer the disease; [v] HEV genotype 4 is associated with more obvious and severer clinical manifestations than genotype 3; [vi] no seasonality in its incidence; and [vii] transmission routes remain obscure in most cases (approx. 60%), whereas about 30%, 8%, and 2% are ascribable to zoonotic food-borne transmission, imported infection, and via blood transfusion, respectively.

Original language	English
Pages (from-to)	384-391
Number of pages	8
Journal	Acta Hepatologica Japonica
Volume	47
Issue number	8
DOIs	https://doi.org/10.2957/kanzo.47.384
Publication status	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2957/kanzo.47.384

Cite this

Abe, T., Aikawa, T., Akahane, Y., Arai, M., Asahina, Y., Atarashi, Y., Chayama, K., Harada, H., Hashimoto, N., Hori, A., Ichida, T., Ikeda, H., Ishikawa, A., Ito, T., Kang, J. H., Karino, Y., Kato, H., Kato, M., Kawakami, M., ... Mishiro, S. (2006). Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide. Acta Hepatologica Japonica, 47(8), 384-391. https://doi.org/10.2957/kanzo.47.384

Abe, T, Aikawa, T, Akahane, Y, Arai, M, Asahina, Y, Atarashi, Y, Chayama, K, Harada, H, Hashimoto, N, Hori, A, Ichida, T, Ikeda, H, Ishikawa, A, Ito, T, Kang, JH, Karino, Y, Kato, H, Kato, M, Kawakami, M, Kitajima, N, Kitamura, T, Masaki, N, Matsubayashi, K, Matsuda, H, Matsui, A, Michitaka, K, Mihara, H, Miyaji, K, Miyakawa, H, Mizuo, H, Mochida, S, Moriyama, M, Nishiguchi, S, Okada, K, Saito, H, Sakugawa, H, Shibata, M, Suzuki, K, Takahashi, K, Yamada, G, Yamamoto, K, Yamanaka, T, Yamato, H, Yano, K & Mishiro, S 2006, 'Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide', Acta Hepatologica Japonica, vol. 47, no. 8, pp. 384-391. https://doi.org/10.2957/kanzo.47.384

@article{45c21e3991d14bb6816b7dc7084f284e,

title = "Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide",

abstract = "To know the reality of hepatitis E virus (HEV) infections in Japan, quite obscure until a few years ago, we have collected a total of 254 human cases of HEV infection, and analyzed for demographic, epidemiological, and virological characteristics. As a result, we now know [i] HEV has penetrated nationwide from Hokkaido to Okinawa; [ii] hepatitis E is a disease of middle-aged people (approx. 50 years old in average) with a predominance of male over female (approx. 3.5 vs 1); [iii] HEV strains of genotype 3 and 4 are autochthonous in Japan, but the latter is present almost exclusively in Hokkaido; [iv] the older the age the severer the disease; [v] HEV genotype 4 is associated with more obvious and severer clinical manifestations than genotype 3; [vi] no seasonality in its incidence; and [vii] transmission routes remain obscure in most cases (approx. 60%), whereas about 30%, 8%, and 2% are ascribable to zoonotic food-borne transmission, imported infection, and via blood transfusion, respectively.",

author = "Toshinori Abe and Tatsuya Aikawa and Yoshihiro Akahane and Masahiro Arai and Yasuhiro Asahina and Yoshinari Atarashi and Kazuaki Chayama and Hideharu Harada and Naoaki Hashimoto and Akiko Hori and Takafumi Ichida and Hiroki Ikeda and Akihisa Ishikawa and Takayoshi Ito and Kang, {Jong Hon} and Yoshiyasu Karino and Hideaki Kato and Masaru Kato and Mari Kawakami and Naoto Kitajima and Tsuneo Kitamura and Naohiko Masaki and Keiji Matsubayashi and Hiroyuki Matsuda and Atsushi Matsui and Kojiro Michitaka and Hiroshi Mihara and Katsuhiko Miyaji and Hiroshi Miyakawa and Hitoshi Mizuo and Satoshi Mochida and Mitsuhiko Moriyama and Shuhei Nishiguchi and Katsuo Okada and Hidetsugu Saito and Hiroshi Sakugawa and Minoru Shibata and Kazuyuki Suzuki and Kazuaki Takahashi and Gotaro Yamada and Kazuhide Yamamoto and Taro Yamanaka and Hiroaki Yamato and Koji Yano and Shunji Mishiro",

year = "2006",

doi = "10.2957/kanzo.47.384",

language = "English",

volume = "47",

pages = "384--391",

journal = "Acta Hepatologica Japonica",

issn = "0451-4203",

publisher = "Japan Society of Hepatology",

number = "8",

}

TY - JOUR

T1 - Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide

AU - Abe, Toshinori

AU - Aikawa, Tatsuya

AU - Akahane, Yoshihiro

AU - Arai, Masahiro

AU - Asahina, Yasuhiro

AU - Atarashi, Yoshinari

AU - Chayama, Kazuaki

AU - Harada, Hideharu

AU - Hashimoto, Naoaki

AU - Hori, Akiko

AU - Ichida, Takafumi

AU - Ikeda, Hiroki

AU - Ishikawa, Akihisa

AU - Ito, Takayoshi

AU - Kang, Jong Hon

AU - Karino, Yoshiyasu

AU - Kato, Hideaki

AU - Kato, Masaru

AU - Kawakami, Mari

AU - Kitajima, Naoto

AU - Kitamura, Tsuneo

AU - Masaki, Naohiko

AU - Matsubayashi, Keiji

AU - Matsuda, Hiroyuki

AU - Matsui, Atsushi

AU - Michitaka, Kojiro

AU - Mihara, Hiroshi

AU - Miyaji, Katsuhiko

AU - Miyakawa, Hiroshi

AU - Mizuo, Hitoshi

AU - Mochida, Satoshi

AU - Moriyama, Mitsuhiko

AU - Nishiguchi, Shuhei

AU - Okada, Katsuo

AU - Saito, Hidetsugu

AU - Sakugawa, Hiroshi

AU - Shibata, Minoru

AU - Suzuki, Kazuyuki

AU - Takahashi, Kazuaki

AU - Yamada, Gotaro

AU - Yamamoto, Kazuhide

AU - Yamanaka, Taro

AU - Yamato, Hiroaki

AU - Yano, Koji

AU - Mishiro, Shunji

PY - 2006

Y1 - 2006

N2 - To know the reality of hepatitis E virus (HEV) infections in Japan, quite obscure until a few years ago, we have collected a total of 254 human cases of HEV infection, and analyzed for demographic, epidemiological, and virological characteristics. As a result, we now know [i] HEV has penetrated nationwide from Hokkaido to Okinawa; [ii] hepatitis E is a disease of middle-aged people (approx. 50 years old in average) with a predominance of male over female (approx. 3.5 vs 1); [iii] HEV strains of genotype 3 and 4 are autochthonous in Japan, but the latter is present almost exclusively in Hokkaido; [iv] the older the age the severer the disease; [v] HEV genotype 4 is associated with more obvious and severer clinical manifestations than genotype 3; [vi] no seasonality in its incidence; and [vii] transmission routes remain obscure in most cases (approx. 60%), whereas about 30%, 8%, and 2% are ascribable to zoonotic food-borne transmission, imported infection, and via blood transfusion, respectively.

AB - To know the reality of hepatitis E virus (HEV) infections in Japan, quite obscure until a few years ago, we have collected a total of 254 human cases of HEV infection, and analyzed for demographic, epidemiological, and virological characteristics. As a result, we now know [i] HEV has penetrated nationwide from Hokkaido to Okinawa; [ii] hepatitis E is a disease of middle-aged people (approx. 50 years old in average) with a predominance of male over female (approx. 3.5 vs 1); [iii] HEV strains of genotype 3 and 4 are autochthonous in Japan, but the latter is present almost exclusively in Hokkaido; [iv] the older the age the severer the disease; [v] HEV genotype 4 is associated with more obvious and severer clinical manifestations than genotype 3; [vi] no seasonality in its incidence; and [vii] transmission routes remain obscure in most cases (approx. 60%), whereas about 30%, 8%, and 2% are ascribable to zoonotic food-borne transmission, imported infection, and via blood transfusion, respectively.

UR - http://www.scopus.com/inward/record.url?scp=33947143184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947143184&partnerID=8YFLogxK

U2 - 10.2957/kanzo.47.384

DO - 10.2957/kanzo.47.384

M3 - Article

AN - SCOPUS:33947143184

SN - 0451-4203

VL - 47

SP - 384

EP - 391

JO - Acta Hepatologica Japonica

JF - Acta Hepatologica Japonica

IS - 8

ER -

Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this