Demonstration of characteristic skin surface contours of extramammary Paget's disease and parapsoriasis en plaque by image analysis of negative impression replicas

Katsuko Kikuchi, Setsuya Aiba, Ken ichiro O'Goshi, Motohiro Yanai, Motoji Takahashi, Hidefumi Kasai, Hachiro Tagami

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The surface contours of lesional skin of certain skin diseases, such as parapsoriasis en plaque (PEP) and extramammary Paget's disease (EMPD), in which there is a massive infiltration by non-epidermal cells, looks somewhat different from that of the adjacent normal skin, needless to state that they are apparently different from that of ordinary chronic inflammatory dermatoses where we found acanthotic epidermis accompanied by hyperkeratosis. We attempted to objectively characterize these unique skin surface changes qualitatively and quantitatively using non-invasive methods. Negative impression replicas were taken from the lesional skin of patients with EMPD or PEP as well as from the adjacent uninvolved skin. The findings were confirmed histologically. The replicas were examined by using computerized image analysis. Several parameters were analyzed that correlate with the changes in the anisotropy of the skin furrows (VC1), average skin roughness (KSD), average length of skin furrows (LEN), and number of skin furrows (NUM). There were significant decreases in KSD and NUM in EMPD, indicating a smoother skin surface in the lesional skin than in the adjacent normal skin. In contrast, the PEP lesion had an increase in VC1 and LEN and a decrease in NUM, which suggests larger skin ridges in the lesional skin than in the uninvolved skin. Thus the unique skin surface of the cutaneous disorders accompanied by epidermal invasion by non-epidermal cells, such as EMPD and PEP, was characterized both qualitatively and quantitatively using computerized image analysis of negative impression replicas.

Original languageEnglish
Pages (from-to)20-28
Number of pages9
JournalJournal of Dermatological Science
Volume30
Issue number1
DOIs
Publication statusPublished - 2002 Oct 1
Externally publishedYes

Fingerprint

Parapsoriasis
Extramammary Paget's Disease
Image analysis
Skin
Demonstrations
Skin Diseases

Keywords

  • Extramammary Paget's disease
  • Image analysis
  • Parapsoriasis en plaque
  • Replica
  • Skin surface contour

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Demonstration of characteristic skin surface contours of extramammary Paget's disease and parapsoriasis en plaque by image analysis of negative impression replicas. / Kikuchi, Katsuko; Aiba, Setsuya; O'Goshi, Ken ichiro; Yanai, Motohiro; Takahashi, Motoji; Kasai, Hidefumi; Tagami, Hachiro.

In: Journal of Dermatological Science, Vol. 30, No. 1, 01.10.2002, p. 20-28.

Research output: Contribution to journalArticle

Kikuchi, Katsuko ; Aiba, Setsuya ; O'Goshi, Ken ichiro ; Yanai, Motohiro ; Takahashi, Motoji ; Kasai, Hidefumi ; Tagami, Hachiro. / Demonstration of characteristic skin surface contours of extramammary Paget's disease and parapsoriasis en plaque by image analysis of negative impression replicas. In: Journal of Dermatological Science. 2002 ; Vol. 30, No. 1. pp. 20-28.
@article{a1480d1699824aa9b3178d04bf1121c9,
title = "Demonstration of characteristic skin surface contours of extramammary Paget's disease and parapsoriasis en plaque by image analysis of negative impression replicas",
abstract = "The surface contours of lesional skin of certain skin diseases, such as parapsoriasis en plaque (PEP) and extramammary Paget's disease (EMPD), in which there is a massive infiltration by non-epidermal cells, looks somewhat different from that of the adjacent normal skin, needless to state that they are apparently different from that of ordinary chronic inflammatory dermatoses where we found acanthotic epidermis accompanied by hyperkeratosis. We attempted to objectively characterize these unique skin surface changes qualitatively and quantitatively using non-invasive methods. Negative impression replicas were taken from the lesional skin of patients with EMPD or PEP as well as from the adjacent uninvolved skin. The findings were confirmed histologically. The replicas were examined by using computerized image analysis. Several parameters were analyzed that correlate with the changes in the anisotropy of the skin furrows (VC1), average skin roughness (KSD), average length of skin furrows (LEN), and number of skin furrows (NUM). There were significant decreases in KSD and NUM in EMPD, indicating a smoother skin surface in the lesional skin than in the adjacent normal skin. In contrast, the PEP lesion had an increase in VC1 and LEN and a decrease in NUM, which suggests larger skin ridges in the lesional skin than in the uninvolved skin. Thus the unique skin surface of the cutaneous disorders accompanied by epidermal invasion by non-epidermal cells, such as EMPD and PEP, was characterized both qualitatively and quantitatively using computerized image analysis of negative impression replicas.",
keywords = "Extramammary Paget's disease, Image analysis, Parapsoriasis en plaque, Replica, Skin surface contour",
author = "Katsuko Kikuchi and Setsuya Aiba and O'Goshi, {Ken ichiro} and Motohiro Yanai and Motoji Takahashi and Hidefumi Kasai and Hachiro Tagami",
year = "2002",
month = "10",
day = "1",
doi = "10.1016/S0923-1811(02)00045-2",
language = "English",
volume = "30",
pages = "20--28",
journal = "Journal of Dermatological Science",
issn = "0923-1811",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Demonstration of characteristic skin surface contours of extramammary Paget's disease and parapsoriasis en plaque by image analysis of negative impression replicas

AU - Kikuchi, Katsuko

AU - Aiba, Setsuya

AU - O'Goshi, Ken ichiro

AU - Yanai, Motohiro

AU - Takahashi, Motoji

AU - Kasai, Hidefumi

AU - Tagami, Hachiro

PY - 2002/10/1

Y1 - 2002/10/1

N2 - The surface contours of lesional skin of certain skin diseases, such as parapsoriasis en plaque (PEP) and extramammary Paget's disease (EMPD), in which there is a massive infiltration by non-epidermal cells, looks somewhat different from that of the adjacent normal skin, needless to state that they are apparently different from that of ordinary chronic inflammatory dermatoses where we found acanthotic epidermis accompanied by hyperkeratosis. We attempted to objectively characterize these unique skin surface changes qualitatively and quantitatively using non-invasive methods. Negative impression replicas were taken from the lesional skin of patients with EMPD or PEP as well as from the adjacent uninvolved skin. The findings were confirmed histologically. The replicas were examined by using computerized image analysis. Several parameters were analyzed that correlate with the changes in the anisotropy of the skin furrows (VC1), average skin roughness (KSD), average length of skin furrows (LEN), and number of skin furrows (NUM). There were significant decreases in KSD and NUM in EMPD, indicating a smoother skin surface in the lesional skin than in the adjacent normal skin. In contrast, the PEP lesion had an increase in VC1 and LEN and a decrease in NUM, which suggests larger skin ridges in the lesional skin than in the uninvolved skin. Thus the unique skin surface of the cutaneous disorders accompanied by epidermal invasion by non-epidermal cells, such as EMPD and PEP, was characterized both qualitatively and quantitatively using computerized image analysis of negative impression replicas.

AB - The surface contours of lesional skin of certain skin diseases, such as parapsoriasis en plaque (PEP) and extramammary Paget's disease (EMPD), in which there is a massive infiltration by non-epidermal cells, looks somewhat different from that of the adjacent normal skin, needless to state that they are apparently different from that of ordinary chronic inflammatory dermatoses where we found acanthotic epidermis accompanied by hyperkeratosis. We attempted to objectively characterize these unique skin surface changes qualitatively and quantitatively using non-invasive methods. Negative impression replicas were taken from the lesional skin of patients with EMPD or PEP as well as from the adjacent uninvolved skin. The findings were confirmed histologically. The replicas were examined by using computerized image analysis. Several parameters were analyzed that correlate with the changes in the anisotropy of the skin furrows (VC1), average skin roughness (KSD), average length of skin furrows (LEN), and number of skin furrows (NUM). There were significant decreases in KSD and NUM in EMPD, indicating a smoother skin surface in the lesional skin than in the adjacent normal skin. In contrast, the PEP lesion had an increase in VC1 and LEN and a decrease in NUM, which suggests larger skin ridges in the lesional skin than in the uninvolved skin. Thus the unique skin surface of the cutaneous disorders accompanied by epidermal invasion by non-epidermal cells, such as EMPD and PEP, was characterized both qualitatively and quantitatively using computerized image analysis of negative impression replicas.

KW - Extramammary Paget's disease

KW - Image analysis

KW - Parapsoriasis en plaque

KW - Replica

KW - Skin surface contour

UR - http://www.scopus.com/inward/record.url?scp=0036804671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036804671&partnerID=8YFLogxK

U2 - 10.1016/S0923-1811(02)00045-2

DO - 10.1016/S0923-1811(02)00045-2

M3 - Article

C2 - 12354416

AN - SCOPUS:0036804671

VL - 30

SP - 20

EP - 28

JO - Journal of Dermatological Science

JF - Journal of Dermatological Science

SN - 0923-1811

IS - 1

ER -