Dependence of elevated mesenteric arteriolar tone on glucocorticoids in spontaneously hypertensive rats.

Hidekazu Suzuki, B. W. Zweifach, G. W. Schmid-Schönbein

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study is designed to explore the effect of adrenal glucocorticoids on arteriolar behavior under steady state conditions in spontaneously hypertensive rats (SHR) compared with their normotensive controls, the Wistar Kyoto (WKY) rats. Mesenteric arterioles were observed by intravital microscopy under general anesthesia and arteriolar diameters were measured. At the end of each experiment, papaverine was topically applied to determine maximum diameter of the vessels for which arteriolar tone was computed. The adrenal contribution to the atypical arteriolar tone in SHR was explored by subjecting them to bilateral adrenalectomy with or without glucocorticoid replacement therapy. Adrenalectomy led to a reduction in the elevated blood pressure in SHR to normotensive levels, which could be restored to its hypertensive level by treatment with dexamethasone. Adrenalectomy had so significant effect on blood pressure in WKY rats, although administration of dexamethasone but not aldosterone did lead to an elevation of the blood pressure in sham-operated WKY. Arteriolar tone in SHR was set at a higher steady state level than in WKY rats. In adrenalectomized SHR, tone fell to the levels observed in WKY rats. This decrease in arteriolar tone in the adrenalectomized SHR could in turn be restored to the hypertensive levels with dexamethasone but not aldosterone. Our results suggest that the enhancement of arteriolar tone, as well as the high blood pressure in SHR, may be related to the above normal levels of adrenal glucocorticoids present in the bloodstream.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalInternational journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation
Volume15
Issue number6
Publication statusPublished - 1995 Nov
Externally publishedYes

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Inbred SHR Rats
Glucocorticoids
Inbred WKY Rats
Adrenalectomy
Dexamethasone
Blood Pressure
Aldosterone
Papaverine
Arterioles
General Anesthesia
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Dependence of elevated mesenteric arteriolar tone on glucocorticoids in spontaneously hypertensive rats. / Suzuki, Hidekazu; Zweifach, B. W.; Schmid-Schönbein, G. W.

In: International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation, Vol. 15, No. 6, 11.1995, p. 309-315.

Research output: Contribution to journalArticle

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