Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo

M. Kobayashi, K. Suganuma, N. Shimazaki, E. Ogawa, Tsunenori Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We studied the dependence of a perpendicular pressure to the luminal surface on the heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. We proposed the combination use of our laser-mediated thermal balloon and drug coated balloon (DCB) to enhance a drug delivery performance. We prospected that the perpendicular pressure, which was applied directly to the luminal surface by balloon dilatation, would enhance the quantity of DCB drug delivered into artery wall. To simulate our laser thermal balloon heating, 63°C preheated artery samples were prepared by heated saline dropping for 15 s, and then these samples were dipped in 37°C saline for 15 s. Non-heated artery samples were prepared by dipping in 37°C saline for 30 s. The perpendicular pressure up to 10 atm corresponding to DCB dilatation pressure was added directly to these artery samples by fluorescence Rhodamine B solution for 30 s. The quantity of drug delivered was microscopically measured with fluorescence brightness in the cross-section of the drug delivered artery samples. We found drastic drug delivery increase at 8 atm using the pre-heated artery sample. Delamination of intima layer was observed by EVG stained cross-sectional specimens with 8 atm in the pre-heated artery sample. We think this drastic pressure dependence on the heating drug delivery performance might be corresponding to increase in permeability of drug into the artery wall originated to morphology change in intima.

Original languageEnglish
Title of host publicationDiagnostic and Therapeutic Applications of Light in Cardiology 2018
PublisherSPIE
Volume10471
ISBN (Electronic)9781510614277
DOIs
Publication statusPublished - 2018 Jan 1
EventDiagnostic and Therapeutic Applications of Light in Cardiology 2018 - San Francisco, United States
Duration: 2018 Jan 272018 Jan 28

Other

OtherDiagnostic and Therapeutic Applications of Light in Cardiology 2018
CountryUnited States
CitySan Francisco
Period18/1/2718/1/28

Fingerprint

Balloons
balloons
arteries
Drug delivery
Carotid Arteries
Heating
delivery
drugs
Lasers
Swine
Hot Temperature
Pressure
heating
Arteries
Pharmaceutical Preparations
lasers
rhodamine B
Fluorescence
Dilatation
Delamination

Keywords

  • Drug delivery
  • Heating
  • Porcine carotid artery wall
  • Pressure

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Kobayashi, M., Suganuma, K., Shimazaki, N., Ogawa, E., & Arai, T. (2018). Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. In Diagnostic and Therapeutic Applications of Light in Cardiology 2018 (Vol. 10471). [104710R] SPIE. https://doi.org/10.1117/12.2289329

Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. / Kobayashi, M.; Suganuma, K.; Shimazaki, N.; Ogawa, E.; Arai, Tsunenori.

Diagnostic and Therapeutic Applications of Light in Cardiology 2018. Vol. 10471 SPIE, 2018. 104710R.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kobayashi, M, Suganuma, K, Shimazaki, N, Ogawa, E & Arai, T 2018, Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. in Diagnostic and Therapeutic Applications of Light in Cardiology 2018. vol. 10471, 104710R, SPIE, Diagnostic and Therapeutic Applications of Light in Cardiology 2018, San Francisco, United States, 18/1/27. https://doi.org/10.1117/12.2289329
Kobayashi M, Suganuma K, Shimazaki N, Ogawa E, Arai T. Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. In Diagnostic and Therapeutic Applications of Light in Cardiology 2018. Vol. 10471. SPIE. 2018. 104710R https://doi.org/10.1117/12.2289329
Kobayashi, M. ; Suganuma, K. ; Shimazaki, N. ; Ogawa, E. ; Arai, Tsunenori. / Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. Diagnostic and Therapeutic Applications of Light in Cardiology 2018. Vol. 10471 SPIE, 2018.
@inproceedings{e5b6f831b7324d01acd82ee273d6fc03,
title = "Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo",
abstract = "We studied the dependence of a perpendicular pressure to the luminal surface on the heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. We proposed the combination use of our laser-mediated thermal balloon and drug coated balloon (DCB) to enhance a drug delivery performance. We prospected that the perpendicular pressure, which was applied directly to the luminal surface by balloon dilatation, would enhance the quantity of DCB drug delivered into artery wall. To simulate our laser thermal balloon heating, 63°C preheated artery samples were prepared by heated saline dropping for 15 s, and then these samples were dipped in 37°C saline for 15 s. Non-heated artery samples were prepared by dipping in 37°C saline for 30 s. The perpendicular pressure up to 10 atm corresponding to DCB dilatation pressure was added directly to these artery samples by fluorescence Rhodamine B solution for 30 s. The quantity of drug delivered was microscopically measured with fluorescence brightness in the cross-section of the drug delivered artery samples. We found drastic drug delivery increase at 8 atm using the pre-heated artery sample. Delamination of intima layer was observed by EVG stained cross-sectional specimens with 8 atm in the pre-heated artery sample. We think this drastic pressure dependence on the heating drug delivery performance might be corresponding to increase in permeability of drug into the artery wall originated to morphology change in intima.",
keywords = "Drug delivery, Heating, Porcine carotid artery wall, Pressure",
author = "M. Kobayashi and K. Suganuma and N. Shimazaki and E. Ogawa and Tsunenori Arai",
year = "2018",
month = "1",
day = "1",
doi = "10.1117/12.2289329",
language = "English",
volume = "10471",
booktitle = "Diagnostic and Therapeutic Applications of Light in Cardiology 2018",
publisher = "SPIE",

}

TY - GEN

T1 - Dependence of perpendicular pressure to luminal surface on heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo

AU - Kobayashi, M.

AU - Suganuma, K.

AU - Shimazaki, N.

AU - Ogawa, E.

AU - Arai, Tsunenori

PY - 2018/1/1

Y1 - 2018/1/1

N2 - We studied the dependence of a perpendicular pressure to the luminal surface on the heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. We proposed the combination use of our laser-mediated thermal balloon and drug coated balloon (DCB) to enhance a drug delivery performance. We prospected that the perpendicular pressure, which was applied directly to the luminal surface by balloon dilatation, would enhance the quantity of DCB drug delivered into artery wall. To simulate our laser thermal balloon heating, 63°C preheated artery samples were prepared by heated saline dropping for 15 s, and then these samples were dipped in 37°C saline for 15 s. Non-heated artery samples were prepared by dipping in 37°C saline for 30 s. The perpendicular pressure up to 10 atm corresponding to DCB dilatation pressure was added directly to these artery samples by fluorescence Rhodamine B solution for 30 s. The quantity of drug delivered was microscopically measured with fluorescence brightness in the cross-section of the drug delivered artery samples. We found drastic drug delivery increase at 8 atm using the pre-heated artery sample. Delamination of intima layer was observed by EVG stained cross-sectional specimens with 8 atm in the pre-heated artery sample. We think this drastic pressure dependence on the heating drug delivery performance might be corresponding to increase in permeability of drug into the artery wall originated to morphology change in intima.

AB - We studied the dependence of a perpendicular pressure to the luminal surface on the heating drug delivery performance using a laser-mediated thermal balloon with porcine carotid artery walls ex vivo. We proposed the combination use of our laser-mediated thermal balloon and drug coated balloon (DCB) to enhance a drug delivery performance. We prospected that the perpendicular pressure, which was applied directly to the luminal surface by balloon dilatation, would enhance the quantity of DCB drug delivered into artery wall. To simulate our laser thermal balloon heating, 63°C preheated artery samples were prepared by heated saline dropping for 15 s, and then these samples were dipped in 37°C saline for 15 s. Non-heated artery samples were prepared by dipping in 37°C saline for 30 s. The perpendicular pressure up to 10 atm corresponding to DCB dilatation pressure was added directly to these artery samples by fluorescence Rhodamine B solution for 30 s. The quantity of drug delivered was microscopically measured with fluorescence brightness in the cross-section of the drug delivered artery samples. We found drastic drug delivery increase at 8 atm using the pre-heated artery sample. Delamination of intima layer was observed by EVG stained cross-sectional specimens with 8 atm in the pre-heated artery sample. We think this drastic pressure dependence on the heating drug delivery performance might be corresponding to increase in permeability of drug into the artery wall originated to morphology change in intima.

KW - Drug delivery

KW - Heating

KW - Porcine carotid artery wall

KW - Pressure

UR - http://www.scopus.com/inward/record.url?scp=85047001902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047001902&partnerID=8YFLogxK

U2 - 10.1117/12.2289329

DO - 10.1117/12.2289329

M3 - Conference contribution

AN - SCOPUS:85047001902

VL - 10471

BT - Diagnostic and Therapeutic Applications of Light in Cardiology 2018

PB - SPIE

ER -