Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination

H. Kakeya, Masaya Imoto, Y. Takahashi, H. Naganawa, T. Takeuchi, K. Umezawa

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Dephostatin, a novel tyrosine phosphatase inhibitor, was isolated from the culture broth of Streptomyces sp. MJ742-NF5. The structure was elucidated to be 2-(N-methyl-N-nitroso)hydroquinone by spectral and chemical analyses of dephostatin and its derivatives.

Original languageEnglish
Pages (from-to)1716-1719
Number of pages4
JournalJournal of Antibiotics
Volume46
Issue number11
Publication statusPublished - 1993

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Protein Tyrosine Phosphatases
Streptomyces
Phosphoric Monoester Hydrolases
Tyrosine
dephostatin
hydroquinone

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Kakeya, H., Imoto, M., Takahashi, Y., Naganawa, H., Takeuchi, T., & Umezawa, K. (1993). Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination. Journal of Antibiotics, 46(11), 1716-1719.

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination. / Kakeya, H.; Imoto, Masaya; Takahashi, Y.; Naganawa, H.; Takeuchi, T.; Umezawa, K.

In: Journal of Antibiotics, Vol. 46, No. 11, 1993, p. 1716-1719.

Research output: Contribution to journalArticle

Kakeya, H, Imoto, M, Takahashi, Y, Naganawa, H, Takeuchi, T & Umezawa, K 1993, 'Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination', Journal of Antibiotics, vol. 46, no. 11, pp. 1716-1719.
Kakeya, H. ; Imoto, Masaya ; Takahashi, Y. ; Naganawa, H. ; Takeuchi, T. ; Umezawa, K. / Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination. In: Journal of Antibiotics. 1993 ; Vol. 46, No. 11. pp. 1716-1719.
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