Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces: Structure determination

Hideaki Kakeya, Masaya Imoto, Yoshikazu Takahashil, Hiroshi Naganawa, Tomio Takeuchi, Kazuo Umezawa

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Dephostatin, a novel tyrosine phosphatase inhibitor, was isolated from the culture broth of Streptomyces sp. MJ742-NF5. The structure was elucidated to be 2-(N-methyl-N-nitroso)hydroquinone by spectral and chemical analyses of dephostatin and its derivatives.

Original languageEnglish
Pages (from-to)1716-1719
Number of pages4
JournalJournal of Antibiotics
Issue number11
Publication statusPublished - 1993 Jul


ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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