Depression of dehydroepiandrosterone in Japanese diabetic men - Comparison between non-insulin-dependent diabetes mellitus and impaired glucose tolerance

Akira Yamauchi, Izumi Takei, Akira Kasuga, Yuko Kitamura, Norimi Ohashi, Satomi Nakano, Sumiyo Takayama, Shinya Nakamoto, Fuminori Katsukawa, Takao Saruta

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Abstract

Hyperglycemia is known to reduce dehydroepiandrosterone (DHEA) circulating levels; however, the mechanism by which hyperglycemia decreases DHEA is not elucidated. In this study, serum DHEA and DHEA sulfate (DHEA-S) levels were compared in 50 men with non-insulin-dependent diabetes mellitus (NIDDM) and 50 age-matched men with impaired glucose tolerance (IGT) receiving only diet therapy. Serum concentrations of DHEA and DHEA-S in the NIDDM group were significantly lower than in the IGT group (7.8 and 9.7 nmol/l vs 3.4 and 4.9 μmol/l, respectively; p < 0.01) but there was no significant difference in immunoreactive insulin between the two groups. When the results from both groups were combined, HbA(1C) was significantly inversely related to DHEA (r = -0.243, p < 0.01) and DHEA-S (r = -0.305, p < 0.01). Immunoreactive insulin showed no correlation with DHEA and DHEA-S. Multiple regression analysis showed that HbA(1C) was independently negatively related to both DHEA and DHEA-S. We conclude that hyperglycemia may decrease serum DHEA and DHEA-S in Japanese men with NIDDM, but the depression of DHEA(-S) is independent of serum insulin level.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalEuropean Journal of Endocrinology
Volume135
Issue number1
Publication statusPublished - 1996 Jul

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Glucose Intolerance
Dehydroepiandrosterone
Type 2 Diabetes Mellitus
Hyperglycemia
Insulin
Serum
Diet Therapy
Dehydroepiandrosterone Sulfate

ASJC Scopus subject areas

  • Endocrinology

Cite this

Depression of dehydroepiandrosterone in Japanese diabetic men - Comparison between non-insulin-dependent diabetes mellitus and impaired glucose tolerance. / Yamauchi, Akira; Takei, Izumi; Kasuga, Akira; Kitamura, Yuko; Ohashi, Norimi; Nakano, Satomi; Takayama, Sumiyo; Nakamoto, Shinya; Katsukawa, Fuminori; Saruta, Takao.

In: European Journal of Endocrinology, Vol. 135, No. 1, 07.1996, p. 101-104.

Research output: Contribution to journalArticle

Yamauchi, A, Takei, I, Kasuga, A, Kitamura, Y, Ohashi, N, Nakano, S, Takayama, S, Nakamoto, S, Katsukawa, F & Saruta, T 1996, 'Depression of dehydroepiandrosterone in Japanese diabetic men - Comparison between non-insulin-dependent diabetes mellitus and impaired glucose tolerance', European Journal of Endocrinology, vol. 135, no. 1, pp. 101-104.
Yamauchi, Akira ; Takei, Izumi ; Kasuga, Akira ; Kitamura, Yuko ; Ohashi, Norimi ; Nakano, Satomi ; Takayama, Sumiyo ; Nakamoto, Shinya ; Katsukawa, Fuminori ; Saruta, Takao. / Depression of dehydroepiandrosterone in Japanese diabetic men - Comparison between non-insulin-dependent diabetes mellitus and impaired glucose tolerance. In: European Journal of Endocrinology. 1996 ; Vol. 135, No. 1. pp. 101-104.
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