Depressive symptoms and small hippocampal volume accelerate the progression to dementia from mild cognitive impairment

Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, M. Mallar Chakravarty, Fernando Caravaggio, Hiroyoshi Takeuchi, Philip Gerretsen, Yusuke Iwata, Raihaan Patel, Benoit H. Mulsant, Ariel Graff-Guerrero

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Previous studies have highlighted that decreased hippocampal volume, an early neural correlate of dementia, is commonly observed in patients with mild cognitive impairment (MCI). However, it is unclear whether neurodegenerative and resultant clinical trajectories are accelerated inMCIpatients with concomitant depressive symptoms, leading to a faster conversion to dementia stages than those who are not depressed. No longitudinal study has investigated whether depressed amnestic MCI (DEP+aMCI) patients show an earlier onset of progression to dementia than non-depressed amnestic MCI (DEP-aMCI) patients and whether progressive hippocampal volume reductions are related in the conversion process. Using data from Alzheimer's Disease Neuroimaging Initiative, we examined 2-year follow-up data from 38 DEP+aMCI patients and 38 matched DEP-aMCI patients and compared their ages of conversion from aMCI to AD and trajectories of progressive hippocampal volume changes. DEP+ and DEP-patients were defined as having baseline Geriatric Depression Scale scores of 5 or above and 0, respectively. DEP+ converters showed earlier ages of conversion to dementia (p = 0.009) and greater left hippocampal volume loss than both DEP-converters and DEP+ non-converters over the 2-year period (p = 0.003, p = 0.001, respectively). These findings could not be explained by changes in total brain volume, differences in their clinical symptoms of dementia, daily functioning, or apolipoprotein E4 genotypes. No difference in conversion rate to dementia or progressive hippocampal volume change was found between DEP+ patients and DEP-patients, which suggested depressive symptoms themselves may not lead to progression of dementia from MCI. In conclusion, there is a synergistic effect of depressive symptoms and smaller left hippocampal volume in MCI patients that accelerates conversion to dementia.

Original languageEnglish
Pages (from-to)743-754
Number of pages12
JournalJournal of Alzheimer's Disease
Volume49
Issue number3
DOIs
Publication statusPublished - 2016

Fingerprint

Dementia
Depression
Apolipoprotein E4
1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride
Cognitive Dysfunction
Neuroimaging
Geriatrics
Longitudinal Studies
Alzheimer Disease
Genotype
Brain

Keywords

  • Dementia
  • Depression
  • Hippocampus
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Depressive symptoms and small hippocampal volume accelerate the progression to dementia from mild cognitive impairment. / Chung, Jun Ku; Plitman, Eric; Nakajima, Shinichiro; Mallar Chakravarty, M.; Caravaggio, Fernando; Takeuchi, Hiroyoshi; Gerretsen, Philip; Iwata, Yusuke; Patel, Raihaan; Mulsant, Benoit H.; Graff-Guerrero, Ariel.

In: Journal of Alzheimer's Disease, Vol. 49, No. 3, 2016, p. 743-754.

Research output: Contribution to journalArticle

Chung, JK, Plitman, E, Nakajima, S, Mallar Chakravarty, M, Caravaggio, F, Takeuchi, H, Gerretsen, P, Iwata, Y, Patel, R, Mulsant, BH & Graff-Guerrero, A 2016, 'Depressive symptoms and small hippocampal volume accelerate the progression to dementia from mild cognitive impairment', Journal of Alzheimer's Disease, vol. 49, no. 3, pp. 743-754. https://doi.org/10.3233/JAD-150679
Chung, Jun Ku ; Plitman, Eric ; Nakajima, Shinichiro ; Mallar Chakravarty, M. ; Caravaggio, Fernando ; Takeuchi, Hiroyoshi ; Gerretsen, Philip ; Iwata, Yusuke ; Patel, Raihaan ; Mulsant, Benoit H. ; Graff-Guerrero, Ariel. / Depressive symptoms and small hippocampal volume accelerate the progression to dementia from mild cognitive impairment. In: Journal of Alzheimer's Disease. 2016 ; Vol. 49, No. 3. pp. 743-754.
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