Abstract
Fluorine-doped diamond-like carbon (F-DLC) has recently drawn a great deal of attention as a more non-thrombogenic coating than conventional DLC for blood-contacting medical devices. We conducted quantitative depth profiling of F-DLC film by X-ray photoelectron spectroscopy (XPS) in order to elucidate the effects of fluorine and fluorine distribution in F-DLC film in connection with the prevention of surface blood adhesion. F-DLC films were prepared on silicon substrates using the radio frequency plasma enhanced chemical vapor deposition method, and the thickness of films was ∼ 50 nm. 50-nm-thick F-DLC film samples were etched at 10-nm thickness intervals using argon plasma, and each surface was examined by XPS. Thereafter, each etched film layer was incubated with platelet-rich plasma isolated from human whole blood, and the platelet-covered area per unit area was evaluated for each surface. XPS spectra showed the localization of doped fluorine in the top-most thin layer of the film. Platelet-covered areas represented progressively larger portions of the surfaces of deeper etched layers, corresponding to the decreasing fluorine content in such sample surfaces. These results indicate that the localized fluorine in the top-most thin layer is one of the key factors in the promotion of the non-thrombogenicity of F-DLC film.
| Original language | English |
|---|---|
| Pages (from-to) | 299-303 |
| Number of pages | 5 |
| Journal | Thin Solid Films |
| Volume | 516 |
| Issue number | 2-4 |
| DOIs | |
| Publication status | Published - 2007 Dec 3 |
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Keywords
- Depth profiling
- Fluorinated diamond-like carbon
- Non-thrombogenicity
- Platelet adhesion
ASJC Scopus subject areas
- Surfaces, Coatings and Films
- Condensed Matter Physics
- Surfaces and Interfaces
Cite this
Depth profiling of fluorine-doped diamond-like carbon (F-DLC) film : Localized fluorine in the top-most thin layer can enhance the non-thrombogenic properties of F-DLC. / Hasebe, Terumitsu; Nagashima, So; Kamijo, Aki; Yoshimura, Taichi; Ishimaru, Tetsuya; Yoshimoto, Yukihiro; Yohena, Satoshi; Kodama, Hideyuki; Hotta, Atsushi; Takahashi, Koki; Suzuki, Tetsuya.
In: Thin Solid Films, Vol. 516, No. 2-4, 03.12.2007, p. 299-303.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depth profiling of fluorine-doped diamond-like carbon (F-DLC) film
T2 - Localized fluorine in the top-most thin layer can enhance the non-thrombogenic properties of F-DLC
AU - Hasebe, Terumitsu
AU - Nagashima, So
AU - Kamijo, Aki
AU - Yoshimura, Taichi
AU - Ishimaru, Tetsuya
AU - Yoshimoto, Yukihiro
AU - Yohena, Satoshi
AU - Kodama, Hideyuki
AU - Hotta, Atsushi
AU - Takahashi, Koki
AU - Suzuki, Tetsuya
PY - 2007/12/3
Y1 - 2007/12/3
N2 - Fluorine-doped diamond-like carbon (F-DLC) has recently drawn a great deal of attention as a more non-thrombogenic coating than conventional DLC for blood-contacting medical devices. We conducted quantitative depth profiling of F-DLC film by X-ray photoelectron spectroscopy (XPS) in order to elucidate the effects of fluorine and fluorine distribution in F-DLC film in connection with the prevention of surface blood adhesion. F-DLC films were prepared on silicon substrates using the radio frequency plasma enhanced chemical vapor deposition method, and the thickness of films was ∼ 50 nm. 50-nm-thick F-DLC film samples were etched at 10-nm thickness intervals using argon plasma, and each surface was examined by XPS. Thereafter, each etched film layer was incubated with platelet-rich plasma isolated from human whole blood, and the platelet-covered area per unit area was evaluated for each surface. XPS spectra showed the localization of doped fluorine in the top-most thin layer of the film. Platelet-covered areas represented progressively larger portions of the surfaces of deeper etched layers, corresponding to the decreasing fluorine content in such sample surfaces. These results indicate that the localized fluorine in the top-most thin layer is one of the key factors in the promotion of the non-thrombogenicity of F-DLC film.
AB - Fluorine-doped diamond-like carbon (F-DLC) has recently drawn a great deal of attention as a more non-thrombogenic coating than conventional DLC for blood-contacting medical devices. We conducted quantitative depth profiling of F-DLC film by X-ray photoelectron spectroscopy (XPS) in order to elucidate the effects of fluorine and fluorine distribution in F-DLC film in connection with the prevention of surface blood adhesion. F-DLC films were prepared on silicon substrates using the radio frequency plasma enhanced chemical vapor deposition method, and the thickness of films was ∼ 50 nm. 50-nm-thick F-DLC film samples were etched at 10-nm thickness intervals using argon plasma, and each surface was examined by XPS. Thereafter, each etched film layer was incubated with platelet-rich plasma isolated from human whole blood, and the platelet-covered area per unit area was evaluated for each surface. XPS spectra showed the localization of doped fluorine in the top-most thin layer of the film. Platelet-covered areas represented progressively larger portions of the surfaces of deeper etched layers, corresponding to the decreasing fluorine content in such sample surfaces. These results indicate that the localized fluorine in the top-most thin layer is one of the key factors in the promotion of the non-thrombogenicity of F-DLC film.
KW - Depth profiling
KW - Fluorinated diamond-like carbon
KW - Non-thrombogenicity
KW - Platelet adhesion
UR - http://www.scopus.com/inward/record.url?scp=36048993403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048993403&partnerID=8YFLogxK
U2 - 10.1016/j.tsf.2007.06.033
DO - 10.1016/j.tsf.2007.06.033
M3 - Article
AN - SCOPUS:36048993403
VL - 516
SP - 299
EP - 303
JO - Thin Solid Films
JF - Thin Solid Films
SN - 0040-6090
IS - 2-4
ER -