Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves

Takuya Akiyama, Shunichi Sato, Hiroshi Ashida, Mitsuhiro Terakawa

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Laser-based drug delivery is attractive for the targeting capability due to high spatial controllability of laser energy. Recently, we found that photomechanical waves (PMWs) can transiently increase the permeability of blood vessels in skin, muscle and brain of rats. In this study, we examined the use of annular-shaped PMWs to increase pressure at target depths due to superposition effect of pressure waves. This can increase the permeability of blood vessels located in the specific depth regions, enabling depth-targeted transvascular drug delivery. Annular PMWs were produced by irradiating a laser-absorbing material with annular-shaped pulsed laser beams that were produced by using an axicon lens. We first examined propagation and pressure characteristics of annular PMWs in tissue phantoms and confirmed an increased pressure at a target depth, which can be controlled by changing laser parameters. We injected Evans blue (EB) into a rat tail vein, and annular PMWs (inner diameter, 3 mm; outer diameter, 5 mm) were applied from the myofascial surface of the anterior tibialis muscle. After perfusion fixation, we observed fluorescence originating from EB in the tissue. We observed intense fluorescence at a target depth region of around 5 mm. These results demonstrate the capability of annular PMWs for depth-targeted transvascular drug delivery.

    Original languageEnglish
    Title of host publicationImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
    DOIs
    Publication statusPublished - 2011 Apr 20
    EventImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX - San Francisco, CA, United States
    Duration: 2011 Jan 222011 Jan 25

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume7902
    ISSN (Print)1605-7422

    Other

    OtherImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
    CountryUnited States
    CitySan Francisco, CA
    Period11/1/2211/1/25

    Keywords

    • annular-shaped photomechanical wave
    • depth target
    • transvascular drug delivery

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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  • Cite this

    Akiyama, T., Sato, S., Ashida, H., & Terakawa, M. (2011). Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves. In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX [79020X] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7902). https://doi.org/10.1117/12.874383