Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves

Takuya Akiyama, Shunichi Sato, Hiroshi Ashida, Mitsuhiro Terakawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Laser-based drug delivery is attractive for the targeting capability due to high spatial controllability of laser energy. Recently, we found that photomechanical waves (PMWs) can transiently increase the permeability of blood vessels in skin, muscle and brain of rats. In this study, we examined the use of annular-shaped PMWs to increase pressure at target depths due to superposition effect of pressure waves. This can increase the permeability of blood vessels located in the specific depth regions, enabling depth-targeted transvascular drug delivery. Annular PMWs were produced by irradiating a laser-absorbing material with annular-shaped pulsed laser beams that were produced by using an axicon lens. We first examined propagation and pressure characteristics of annular PMWs in tissue phantoms and confirmed an increased pressure at a target depth, which can be controlled by changing laser parameters. We injected Evans blue (EB) into a rat tail vein, and annular PMWs (inner diameter, 3 mm; outer diameter, 5 mm) were applied from the myofascial surface of the anterior tibialis muscle. After perfusion fixation, we observed fluorescence originating from EB in the tissue. We observed intense fluorescence at a target depth region of around 5 mm. These results demonstrate the capability of annular PMWs for depth-targeted transvascular drug delivery.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7902
DOIs
Publication statusPublished - 2011
EventImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX - San Francisco, CA, United States
Duration: 2011 Jan 222011 Jan 25

Other

OtherImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
CountryUnited States
CitySan Francisco, CA
Period11/1/2211/1/25

Fingerprint

delivery
drugs
Lasers
Pressure
Evans Blue
Pharmaceutical Preparations
blood vessels
Blood Vessels
muscles
Permeability
Blood vessels
Fluorescence
rats
permeability
Muscles
Muscle
Rats
lasers
fluorescence
Tissue

Keywords

  • annular-shaped photomechanical wave
  • depth target
  • transvascular drug delivery

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Akiyama, T., Sato, S., Ashida, H., & Terakawa, M. (2011). Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7902). [79020X] https://doi.org/10.1117/12.874383

Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves. / Akiyama, Takuya; Sato, Shunichi; Ashida, Hiroshi; Terakawa, Mitsuhiro.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7902 2011. 79020X.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Akiyama, T, Sato, S, Ashida, H & Terakawa, M 2011, Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7902, 79020X, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, San Francisco, CA, United States, 11/1/22. https://doi.org/10.1117/12.874383
Akiyama T, Sato S, Ashida H, Terakawa M. Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7902. 2011. 79020X https://doi.org/10.1117/12.874383
Akiyama, Takuya ; Sato, Shunichi ; Ashida, Hiroshi ; Terakawa, Mitsuhiro. / Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7902 2011.
@inproceedings{a3887b135c124fb2a2b9d8200d8bd9c4,
title = "Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves",
abstract = "Laser-based drug delivery is attractive for the targeting capability due to high spatial controllability of laser energy. Recently, we found that photomechanical waves (PMWs) can transiently increase the permeability of blood vessels in skin, muscle and brain of rats. In this study, we examined the use of annular-shaped PMWs to increase pressure at target depths due to superposition effect of pressure waves. This can increase the permeability of blood vessels located in the specific depth regions, enabling depth-targeted transvascular drug delivery. Annular PMWs were produced by irradiating a laser-absorbing material with annular-shaped pulsed laser beams that were produced by using an axicon lens. We first examined propagation and pressure characteristics of annular PMWs in tissue phantoms and confirmed an increased pressure at a target depth, which can be controlled by changing laser parameters. We injected Evans blue (EB) into a rat tail vein, and annular PMWs (inner diameter, 3 mm; outer diameter, 5 mm) were applied from the myofascial surface of the anterior tibialis muscle. After perfusion fixation, we observed fluorescence originating from EB in the tissue. We observed intense fluorescence at a target depth region of around 5 mm. These results demonstrate the capability of annular PMWs for depth-targeted transvascular drug delivery.",
keywords = "annular-shaped photomechanical wave, depth target, transvascular drug delivery",
author = "Takuya Akiyama and Shunichi Sato and Hiroshi Ashida and Mitsuhiro Terakawa",
year = "2011",
doi = "10.1117/12.874383",
language = "English",
isbn = "9780819484390",
volume = "7902",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves

AU - Akiyama, Takuya

AU - Sato, Shunichi

AU - Ashida, Hiroshi

AU - Terakawa, Mitsuhiro

PY - 2011

Y1 - 2011

N2 - Laser-based drug delivery is attractive for the targeting capability due to high spatial controllability of laser energy. Recently, we found that photomechanical waves (PMWs) can transiently increase the permeability of blood vessels in skin, muscle and brain of rats. In this study, we examined the use of annular-shaped PMWs to increase pressure at target depths due to superposition effect of pressure waves. This can increase the permeability of blood vessels located in the specific depth regions, enabling depth-targeted transvascular drug delivery. Annular PMWs were produced by irradiating a laser-absorbing material with annular-shaped pulsed laser beams that were produced by using an axicon lens. We first examined propagation and pressure characteristics of annular PMWs in tissue phantoms and confirmed an increased pressure at a target depth, which can be controlled by changing laser parameters. We injected Evans blue (EB) into a rat tail vein, and annular PMWs (inner diameter, 3 mm; outer diameter, 5 mm) were applied from the myofascial surface of the anterior tibialis muscle. After perfusion fixation, we observed fluorescence originating from EB in the tissue. We observed intense fluorescence at a target depth region of around 5 mm. These results demonstrate the capability of annular PMWs for depth-targeted transvascular drug delivery.

AB - Laser-based drug delivery is attractive for the targeting capability due to high spatial controllability of laser energy. Recently, we found that photomechanical waves (PMWs) can transiently increase the permeability of blood vessels in skin, muscle and brain of rats. In this study, we examined the use of annular-shaped PMWs to increase pressure at target depths due to superposition effect of pressure waves. This can increase the permeability of blood vessels located in the specific depth regions, enabling depth-targeted transvascular drug delivery. Annular PMWs were produced by irradiating a laser-absorbing material with annular-shaped pulsed laser beams that were produced by using an axicon lens. We first examined propagation and pressure characteristics of annular PMWs in tissue phantoms and confirmed an increased pressure at a target depth, which can be controlled by changing laser parameters. We injected Evans blue (EB) into a rat tail vein, and annular PMWs (inner diameter, 3 mm; outer diameter, 5 mm) were applied from the myofascial surface of the anterior tibialis muscle. After perfusion fixation, we observed fluorescence originating from EB in the tissue. We observed intense fluorescence at a target depth region of around 5 mm. These results demonstrate the capability of annular PMWs for depth-targeted transvascular drug delivery.

KW - annular-shaped photomechanical wave

KW - depth target

KW - transvascular drug delivery

UR - http://www.scopus.com/inward/record.url?scp=79954470627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954470627&partnerID=8YFLogxK

U2 - 10.1117/12.874383

DO - 10.1117/12.874383

M3 - Conference contribution

AN - SCOPUS:79954470627

SN - 9780819484390

VL - 7902

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -