Deranged Myocardial Fatty Acid Metabolism in Heart Failure

Tsunehisa Yamamoto, Motoaki Sano

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The heart requires fatty acids to maintain its activity. Various mechanisms regulate my-ocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for which it is known that coordinated control of fatty acid uptake, β-oxidation, and mitochondrial oxidative phosphorylation steps are important for efficient adenosine triphosphate (ATP) production without unwanted side effects. The fatty acids taken up by cardiomyocytes are not only used as substrates for energy production but also for the synthesis of triglycerides and the replacement reaction of fatty acid chains in cell membrane phospholipids. Alterations in fatty acid metabolism affect the structure and function of the heart. Recently, breakthrough studies have focused on the key transcription factors that regulate fatty acid metabolism in cardiomyocytes and the signaling systems that modify their functions. In this article, we reviewed the latest research on the role of fatty acid metabolism in the pathogenesis of heart failure and provide an outlook on future challenges.

Original languageEnglish
Article number996
JournalInternational journal of molecular sciences
Volume23
Issue number2
DOIs
Publication statusPublished - 2022 Jan 1

Keywords

  • ER stress
  • ERR
  • MUFA
  • Membrane fatty acid composition
  • PPAR
  • SCD1
  • SFA
  • SIRT1
  • Triacylglyceride
  • β-oxidation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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